Beecham Group Plc

Kenneth D Hardy

George Burton

Peter Hubert Bentley

Peter H Milner

John P Clayton

Angela W Guest

A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R is phenyl, 4-hydroxyphenyl, or a 5- or 6-membered heterocyclic ring containing up to three heteroatoms selected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen or C.sub.1-6 alkoxy;

Cephalosporin derivatives, and compositions containing them

A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof: ##STR1## wherein R is phenyl 4-hydroxy phenyl, or a 5- 6- membered heterocyclic ring containing up to three heteroatoms selected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen or C.sub.1-6 alkoxy;

Penicillin derivatives and compositions containing them

A class of penicillins with antibacterial activity having formula (I): ##STR1## wherein R.sup.2 is hydrogen or a pharmaceutically acceptable salting ion or in vivo hydrolyzable ester radical and R.sup.1 is hydrogen, a pharmaceutically acceptable salting ion or a pharmaceutically acceptable ester forming radical.

Penicillins

Novel cephalosporin compounds, process of preparation thereof, intermediates useful in the preparation of the cephalosporins, pharmaceutical compositions formulated therefrom for administration and combinations of the cephalosporins in pharmaceutical composition form with clavulanic acid. The cephalosporin compounds are characterized by a 5-membered nitrogen-containing ring in the group in the 3-position of the sulphur-containing ring.

Carbamoyl heterocyclicthio cephalosporins and pharmaceutical

Novel substituted amino methyl esters of penicillins and cephalosporins for oral administration which are much better absorbed than the parent compounds.

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Horsham, United Kingdom

Kenneth D Hardy