Oklahoma State University

Board of Regents for the Oklahoma Agricultural & Mechanical Colleges

Other

Kenneth D Berlin

Benjamin J Scherlag

Mark D Thompson

Gary S Smith

Subbiah Sangiah

Warren T Ford

Krishna Kumar Gnanasekaran

Richard A Bunce

Ralph Lazzara

Eugene S Patterson

Stan A Zisman

Satish V Mulekar

Donghua Howard Zhou

Chun-Lin Chen

Cyril Roy Clarke

Lyle W Spruce

Gregory Lynn Garrison

Shirish N Rajadhyaksha

George Edward Burrows

Jonathan B Gale

Elizabeth M Holt

Cyril R Clarke

Field M Watts, Jr

Surendra R Otiv

Doris Manglaracina Benbrook

Claude Desjardins

Eldon C Nelson

Norman Nevill Durham

Bruce R Bailey, Iii

Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.

Chromane-substituted, tetrahydroquinoline-substituted and thiochromane-substituted heteroarotinoids as anti-cancer agents

Chroman-substituted, tetrahydroquinoline-substituted and thiochroman-substituted heteroarotinoids as anti-cancer agents

Heteroarotinoids containing urea or thiourea linker

3,7-Diazabicyclo�3.3!nonanes and selected derivatives thereof of the general formula: ##STR1## wherein Q=S; Z=CH.sub.2 ; and Y equals an N-acyl or N-alkyl group are disclosed as multiclass antiarrhythmic agents.

N-alkyl and N-acyl derivatives of 3,7-Diazabicyclo-�3.3.1!nonanes and

3,7-Diazabicyclo[3.3.1]nonanes and selected derivatives thereof of the general formula: ##STR1## are disclosed as multiclass antiarrhythmic agents.

N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and

3-7-Diheterabicyclo[3.3.1]nonanes and derivatives thereof are disclosed. Their method of preparation and use as antiarrhythmic agents is given.

3-7-diheterabicyclo (3.3.1)nonanes and derivatives as antiarrhythmic

Salts of 3-azabicyclo[3.3.1]nonanes are used in controlling antiarrhythmic processes and precursors thereof are disclosed.

Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and

Salts of 3-azabicyclo [3.3.1]nonanes as antiarrhythmic agents, and

3-7-Diheterabicylo[3.3.1]nonanes and derivatives thereof are disclosed. Their method of preparation and use as antiarrhythmic agents is given.

Bis-1,3-diazine heterocyclic derivatives as antiarrhythmic agents

Polyheterobicyclotridecane compounds

Novel heteroarotinoid compositions characterized by the formulae: ##STR1## where: X is S or O; OAc is the acetate group ##STR2## and R is --H, --OH, --OCH.sub.3, or --OC.sub.2 H.sub.5 and includes ##STR3## for formulae (1) and (2). Such compositions exhibit activity as anticancer agents.

Heteroarotinoids as anticancer agents

3-7,Diheterabicylo[3.3.1]nonanes and derivatives thereof are disclosed. Their method of preparation and use as antiarrhythmic agents is given.

3-7-diheterabicyclo[3.3.1]nonanes as antiarrhythmic agents

Novel heteroarotinoid compositions characterized by the formulae: ##STR1## where R is H, CH.sub.3 or C.sub.2 H.sub.5 and X is S, S O, O, NCH.sub.3, Si(CH.sub.3).sub.2, N.sup.+ (H)CH.sub.3 [Cl.sup.- ], N.sup.+ (H)CH.sub.3 [Br.sup.- ] or N.sup.+ (alkyl) CH.sub.3 [Cl.sup.- or Br.sup.-) where alkyl is CH.sub.3, C.sub.2 H.sub.5, CH.sub.2 .dbd.CHCH.sub.2 or C.sub.6 H.sub.5 CH.sub.2. Such compositions exhibit activity as anticancer agents.

Heteroarotinoid compounds as anticancer agents

Certain 3-selena-7-aza-bicyclo[3.3.1]nonanes as antiarrhythmic agents

Growing community of inventors

Stillwater, OK, United States of America

Kenneth D Berlin