Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Kenneth Carey Rupert

Christophe Michoud

Yan Lou

Stacy W Remiszewski

Robert Francis Kester

Kang Le

Xiaochun Han

Andrew Forrest Donnell

Paul Gillespie

Steven Gregory Mischke

Norman Kong

Shaoqing Chen

Weiya Yun

Kshitij Chhabilbhai Thakkar

John Anthony Moliterni

Martin Weisel

Disclosed are compounds of Formula I, or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R, R, R, Rand Rare as described in this application, and methods of using said compounds in the treatment of cancer. 

Tetrahydro-benzodiazepinones

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R, R, Rand Rare described in this application, and methods of using said compounds in the treatment of cancer. 

Antiproliferative benzo [B] azepin-2-ones

There are provided compounds of the formula 

Substituted hetero-azepinones

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

Thiazole and thiophene compounds

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Bedminster, NJ, United States of America

Kenneth Carey Rupert