Btg International Limited

The University of Edinburgh

Kenneth Andrew Rose

Richard Lathe

Genevieve Stapleton

Jonathan Robert Seckl

Caroline McKenzie Leckie

Ruth Best

Joyce Lai Wah Yau

Use is provided for a 7&agr;-hydroxy or 7-oxo substituted 3&bgr;-hydroxy-steroid possessing the carbon skeleton of cholesterol, androsterone, pregnenolone or estradiol, or an analogue thereof substituted independently at one or both of the 7- and 3-positions with an ester or ether group, in the manufacture of a pharmaceutical composition for the therapy of neuropsychiatric, immune and/or endocrine disorders or for inducing cognitive enhancement. Uses for Cyp7b enzymes in producing such steroids is also provided together with various novel steroids and test kits and methods for diagnosing the disorders.

Use of 7 &agr;-substituted steroid to treat neuropsychiatric, immune or endocrine disorders

This invention provides novel hippocampus-associated proteins and DNA sequences coding therefor. In an investigation of hippocampus-associated proteins by differential screening of a rat hippocampus cDNA library, a cDNA species encoding a novel protein designated Hct-1 was isolated and shown to be a to cytochromes P450. The use of hybridization probes based on the rat Hct-1 sequence has led to the identification of homologues in other mammalian species.

Hippocampus-associated proteins, DNA sequences coding therefor and uses thereof

Hippocampus-associated proteins; DNA sequences coding therefor and uses

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Edinburgh, United Kingdom

Kenneth Andrew Rose