Blaze Medical Devices, LLC

Tailorpill Technologies, LLC

Other

Kenneth Alfano

Michael Tarasev

Gene Parunak

Aaron Kehrer

Terrance Boyd

Steven Meines

Sumita Chakraborty

A bead mill and an associated bead-mill-based machine for testing mechanical fragility of red blood cells, employing a cartridge configured to contain a sample while cells get stressed via bead oscillation and, in the case of the fragility testing machine, also while lysis levels get detected, for presentation of fragility information.

Method of using bead milling in erythrocyte fragility testing

A method using variable bead-oscillation-based stress parameters, including relative bead dimensionality or other structural features as well as stress duration or intensity or overall magnitude, in inducing different shear stresses in biological samples, for testing the effects of different combinations of various defined stress conditions.

Method and system for inducing controlled and varied fluid stresses by bead oscillation

Bead mill and method of use

A pharmaceutical compounding system having automated micro-dosing capability and using exchangeable source containers containing respective drugs, the system comprising an automated capsule-filling machine configured for compounding: an interface configured for receiving of prescription information for particular patients; and a dispensing head containing a solid-form drug; wherein said drug can be dispensed from said dispensing head by said machine such that the drug's active pharmaceutical ingredient (API) alone can be accurately dosed; and wherein the dispensing head is part of a set of multiple dispensing heads configured for compounding with said system.

Cartridge-based pharmacy compounding system

A method of making a pharmaceutical compounding system having automated micro-dosing capability, the method comprising identifying a technology that can facilitate controlled and automated dispensation of material, such that the dispensation does not necessitate augmentation of material by mass or volume to aid with measurement or manipulation in order to achieve a level of dispensing precision that can be medically acceptable for at least some drug substances; and adapting the technology for prescription-specific operability for producing customized drug products, the adapting comprising configuring the technology for production of pills in prescribed numbers with prescribed drugs at prescribed doses via distinct runs for respective patients.

Method of making a pharmacy compounding system

A vehicle seat feature to provide additional legroom for feet or legs of a rear-facing child in a safety carseat installed in a vehicle seat, by utilizing a bounded cavity or the like in the vehicle seat backrest, which is accessible from the front side of the backrest by feet or legs of a rear-facing child. Such a cavity may in some embodiments be deployable and made available by removing or repositioning a barrier object or the like, which when restored may in effect constitute part of an otherwise normally functional backrest.

Legroom cavity in vehicle backrest for rear-faced child in carseat

A system and associated aspects thereof are disclosed regarding custom-compounding of drug products such as pills and polypills for particular patients, herein involving adaptations of 'micro-dosing' technology to permit sufficiently small and precise amounts of drug substances or optionally formulations thereof to be controllably and automatably handled and dispensed so as to help create customized drug products that do not necessitate bulking or dilution of the drug substances.

Custom-pill compounding system with filler-free capability

The present disclosure describes an apparatus for quantifying the quality degradation of individual stored red blood cell (RBC) units, thereby yielding information to improve decisions regarding their respective allocation, patient suitability, and use. The apparatus for quantifying the quality degradation of individual stored (RBC) units comprises: a hemolysis unit; an optical analysis unit; and a computation unit. This apparatus is amenable to clinical implementation as well as indicative of any given unit's relative viability and thus prospective efficacy. This would provide clinicians with actual data on RBC quality when making decisions about which and how many units to use for transfusion of a given patient. Moreover, deploying this testing throughout the supply chain will improve distribution, planning, and inventory control decisions. A vital aspect of this testing system is the accumulation of copious output and other associated data and the mathematical analyses thereof to optimize algorithms by which to characterize each subsequent test output as meaningfully as possible. While the present invention is directed toward applications in blood quality control, the core technology of 'quantifying RBC fragility via stress-induced hemolysis and subsequent optical and computational analysis' could have broader application, such as in disease diagnosis.

Apparatus to characterize blood and red blood cells via erythrocyte membrane fragility quantification

A method for quantifying the quality degradation of individual stored red blood cell (RBC) units, thereby yielding information to improve decisions regarding their respective allocation, patient suitability, and use. The method comprises: a hemolysis step; an optical analysis step; and a computation step. The method is amenable to clinical implementation as well as indicative of any given unit's relative viability and thus prospective efficacy. This would provide clinicians with actual data on RBC quality when making decisions about which and how many units to use for transfusion of a given patient. Moreover, deploying this testing throughout the supply chain will improve distribution, planning, and inventory control decisions. A vital aspect of this testing method is the accumulation of copious output and other associated data and the mathematical analyses thereof to optimize algorithms by which to characterize each subsequent test output as meaningfully as possible. While the present invention is directed toward applications in blood quality control, the core technology of 'quantifying RBC fragility via stress-induced hemolysis and subsequent optical and computational analysis' could have broader application, such as in disease diagnosis.

Method to characterize blood and red blood cells via erythrocyte membrane fragility quantification

The present disclosure describes an apparatus and associated method for quantifying the quality degradation of individual stored red blood cell (RBC) units, thereby yielding information to improve decisions regarding their respective allocation, patient suitability, and use. This apparatus and the methods of its use are amenable to clinical implementation as well as indicative of any given unit's relative viability and thus prospective efficacy. This would provide clinicians with actual data on RBC quality when making decisions about which and how many units to use for transfusion of a given patient. Moreover, deploying this testing throughout the supply chain will improve distribution, planning, and inventory control decisions. A vital aspect of this testing system is the accumulation of copious output and other associated data and the mathematical analyses thereof to optimize algorithms by which to characterize each subsequent test output as meaningfully as possible. While the present invention is directed toward applications in blood quality control, the core technology of 'quantifying RBC fragility via stress-induced hemolysis and subsequent optical and computational analysis' could have broader application, such as in disease diagnosis. The apparatus for quantifying the quality degradation of individual stored (RBC) units comprises: a hemolysis unit; an optical analysis unit; and a computation unit. Similarly, the associated process for quantifying the quality degradation of individual stored (RBC) units comprises: a hemolysis step; an optical analysis step; and a computation step.

Growing community of inventors

Canton, MI, United States of America

Kenneth Alfano