Genetics Institute, Inc.

Other

The Brigham and Women's Hospital, Inc.

Wyeth

Ono Pharmaceutical Co., Ltd.

Kenneth A Jacobs

John M McCoy

Edward R LaVallie

Lisa A Racie

Vikki A Spaulding

David Merberg

Maurice Treacy

Cheryl Evans

Lynette A Fouser

Dejun Xuan

Debra D Pittman

Michael J Agostino

Kerry Kelleher

McKeough Carlin

Sha Mi

Steven C Clark

Samuel Goldman

Rodney M Hewick

Katherine Jane Turner

Michael R Bowman

Thomas G Gesner

Steven Neben

Joanne Giannotti

Margaret M Golden-Fleet

Edward F Fritsch

D Randall Steinbrink

Joanna Floros

David S Phelps

H William Taeusch

Gordon G Wong

Mary Collins

Lisa Anne Collins-Racie

Hilary Clark

Joseph P Dougherty

Zhijian Lu

Marian S Ellwood

Kim Fechtel

Robert J Steininger, Ii

Edward R La Vallie

Lynette Fouser

Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.

Human GIL-19/AE289 proteins

Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.

Method of treating psoriasis by administering IL-22 antibodies, or binding fragments thereof

Human GIL-19/AE289 polynucleotides and methods of producing the encoded polypeptides

Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.

Megakaryocyte stimulating factors

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Human Gil-19/AE289 polynucleotides

Antibodies that bind to interleukin-22

Composition and method for treating inflammatory disorders

Polynucleotides encoding human CTLA-8 (now known as IL-17F) and related proteins are disclosed. Human CTLA-8 and related proteins, including anti-human IL-17F antibodies, and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpes CTLA-8 proteins are also provided.

Antibodies to human IL-17F and other CTLA-8-related proteins

Secreted proteins

Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.

Method of inhibiting angiogenesis using secreted proteins

Growing community of inventors

Newton, MA, United States of America

Kenneth A Jacobs