Mect Corporation

Rikagaku Kenkyusho

Kenkichi Tomita

Mamoru Sugimoto

Tomoya Ogawa

Takayuki Ishii

Masaaki Numata

Makoto Tanaka

Tae Yasunaga

Mariko Ishii

Makiko Kasano

Naokazu Sugiyama

Isao Suda

Nobuyuki Kibushi

Ryoichi Osawa

Masanori Kobayashi

Yukishige Ito

Takeshi Miyata

Shuji Fujita

Masanori Kobayashiu

An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts, thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

Method for modulating the immune system

An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

Methods for inhibiting the chemotaxis of neutrophils

Anti-inflammatory agent

A preparation is useful for treating renal disease, such as nephritis and especially nephrosis (nephrotic syndrome), which comprises an effective amount of N-acetylneuraminic acid shown by the formula ##STR1## wherein, when n is 1, Z represents hydrogens, lithium, potassium, sodium, ammonium or organic ammonium, and when n is 2, Z represents calcium, barium or magnesium, and a pharmacologically acceptable carrier.

Preparation for treating renal disease

GM.sub.3 analogous compound (I) below: ##STR1## wherein one of R.sup.2 and R.sup.3 represents a neuramic acid group represented by general formula (V): ##STR2## R.sup.5 represents ##STR3## or hydrogen; R.sup.6 represents hydrogen or a ceramide group represented by general formula (VI): ##STR4##

GM.sub.3 analogous compound

The present invention relates to sulfated oligosaccharides or their derivatives such as the following compound and being useful for diagnosing or treating diseases such as immunity-related diseases and mucopolysaccharide diseases. ##STR1## (M is an alkali metal).

Sulfated oligosaccharides and derivatives thereof

Growing community of inventors

Tokyo, Japan

Kenkichi Tomita