Yamasa Shoyu Kabushiki Kaisha

Other

Kenjiro Kodama

Akira Kuninaka

Hitoshi Kusakabe

Haruhiko Machida

Kenji Soda

Yuichiro Midorikawa

Manami Morozumi

Hiroshi Yoshino

Haruo Misono

Yuichirow Midorikawa

Mineo Saneyoshi

An antitumor composition comprising a pharmacologically effective quantity of an ester of 1-.beta.-D-arabinofuranosylcytosine-5'-phosphate represented by the general formula ##STR1## where R is a monovalent aliphatic hydrocarbon group having 14 to 23 carbon atoms, and A designates a hydrogen atom or a pharmaceutically-acceptable alkali cation, and a vehicle is effective when administered by a non-injection method, particularly orally.

Antitumor compositions for non-injection administration

A new composition of matter, 1-.beta.-D-arabinofuranosylcytosine-5'-oleyl phosphate, represented by the structural formula ##STR1## and its pharmaceutically-acceptable salts exhibit antitumor properties and are especially useful for oral administration thereof.

1-.beta.-D-Arabinofuranosylcytosine-5'-oleyl phosphate and salts thereof

An L-lysine .alpha.-oxidase, that is, a novel L-amino acid oxidase having very high substrate-specificity to L-lysine is produced by culturing a specific microorganism belonging to Trichoderma in a medium.

L-Lysine .alpha.-oxidase

The enzyme pterin deaminase may be used as an antitumor agent, and can be produced from cultures of the fungal genera Aspergillus, Mucor, Rhizopus, and Penicillium.

Process for producing pterin deaminases having antitumor activity

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Choshi, Japan

Kenjiro Kodama