Chugai Seiyaku Kabushiki Kaisha

Koito Manufacturing Company, Ltd.

Pharmalogicals Research Pte. Ltd.

Ciea International Inc.

The University of Tokyo

Toyo Tire Corporation

Grid IP Pte. Ltd

Hashimoto, Shinichi

Matsushima, Kouji

Kenji Yoshida

Masayuki Tsuchiya

Masashi Katayama

Takahito Osawa

Miho Watanabe

Masami Suzuki

Yu Jau Chen

Koichi Matsubara

Mamoru Kosuge

Juliana Sim

Etsuko Fujii

Shinichi Hashimoto

Kouji Matsushima

Akinori Matsumoto

Hiroyuki Aburatani

Hirotaka Ito

Yuichi Hirata

Shumpei Ishikawa

Tatsuhiko Yamamichi

Shuji Matsuura

Ryo Takada

Kazuki Kajiyama

Kazuyuki Ojima

It is intended to disclose an antibody which binds to DLL3 protein. Preferably, the antibody of the present invention recognizes a region from amino acids 216 to 492 in human DLL3 having the amino acid sequence as set forth in SEQ ID NO: 1. The present invention also provides a pharmaceutical composition, for example, an anticancer agent, comprising the antibody of the present invention as an active ingredient. The present invention further discloses a method for diagnosing cancer using the antibody of the present invention and a diagnostic drug for cancer comprising the antibody of the present invention.

Anti-DLL3 antibody

A method for manufacturing an optical component having an optical surface includes: injecting a molten resin into a cavity; curing the molten resin to form the optical component; and taking the optical component out from the movable mold by moving the movable mold away from the fixed mold, and piercing a part of the optical surface (first incident surface) of the optical component attached to the movable mold by the protruding pin, and then wherein a tip end face of the protruding pin includes: a first surface; and a second surface having an area smaller than an area of the first surface, and extending continuously from the first surface in a curved form, the second surface being located on at least a part of an outer circumferential edge portion of the tip end face, that is, a tip end in the first direction.

Method and apparatus for manufacturing optical component, and optical component

A projection lens formed of a light-transmitting resin including an incidence part on which light is incident, an emission part, a peripheral edge portion, and a thick part. Light is incident on the incidence part. The emission part emits the light incident from the incidence part. The peripheral edge portion is provided at a boundary between the incidence part and the emission part. The thick part is provided at a part of the peripheral edge portion, made thicker in an optical axis direction than other parts of the peripheral edge portion and having a gate mark formed at least on a part of an outer peripheral surface of the thick part.

Projection lens with peripheral thick part and vehicle lamp provided with the same

A vehicle lamp according to an aspect of the present invention includes a light source, a metal light-source stage including a light-source mounting portion, and a lens member that emits light from the light source toward the front of the lamp. The light-source stage includes a support portion for the lens member. The lens member includes a leg projecting toward the light-source stage and having an end that is supported by the support portion. The support portion includes three projections that abut the leg in a state in which the leg is supported by the support portion and position the lens member in a direction of an optical axis. The three projections are positioned relative to one another such that at least a portion of the light source lies in an extension range of a triangle with vertices given by the three projections.

Vehicle lamp

Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.

Proteins expressed in NK cells

An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells. The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.

Methods of generating and using antibody-producing cells

Method of producing a nucleic acid encoding an antibody

The present invention aims to provide a novel gene having a reverse transcriptase motif. The invention isolates a novel gene having a reverse transcriptase motif, and gives its complete base sequence determined. The invention also provides a protein encoded by the gene, and an antibody against the protein. The use of them is useful in developing a method for detecting telomerase activity, a method for detecting a cancer cell, a telomerase activity inhibitor, and a method for screening a telomerase activity inhibitor.

Proteins having a reverse transcriptase motif

CRT-1 gene having reverse transcriptase motif

Growing community of inventors

Shizuoka, Japan

Kenji Yoshida