Chugai Seiyaku Kabushiki Kaisha

Kenji Yasugi

Tsuyoshi Shimoboji

Teruo Nakamura

Mika Sato

Tomoko Yasugi

Yoshihiro Tampo

Takashi Nakai

Tai Hirakura

The present invention provides a hyaluronic acid derivative containing a disaccharide unit represented by formula (I) or formula (I) and (II), and a complex containing the hyaluronic acid derivative and a drug.

Hyaluronic acid derivative having amino acid and steryl group introduced thereinto

The present invention provides a water-soluble modified HA practically used as a drug carrier and a production method thereof. The present invention provides: a water-soluble modified hyaluronic acid, the residence time in blood of which is elongated to a practical level, which is produced by introducing a substituent into the carboxy group of the glucuronic acid of hyaluronic acid or a derivative thereof, via an amide bond, at a lower limit of an introduction ratio of 5 mole % or more, using a BOP condensing agent in an aprotic polar solvent; and a production method thereof. Moreover, by cross-linking the modified hyaluronic acid, the present invention provides a hyaluronic acid gel capable of extremely long drug sustained-release even at the same cross-linking functional group introduction ratio as that of the conventionally known gel.

Process for producing water-soluble hyaluronic acid modification

The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.

Derivative of hyaluronic acid modified with amino-carboxylic acid

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Shizuoka, Japan

Kenji Yasugi