Otsuka Pharmaceutical Company, Limited

Kenji Watanabe

Nobuaki Ito

Takumi Sumida

Kunio Oshima

Masatoshi Chihiro

Isao Takemura

Hironobu Ishiyama

Hidetaka Hiyama

Hideki Kitagaki

Junpei Haruta

Yoko Sakamoto

Hideki Kawasome

Kazuhiko Fujita

Satoshi Yamada

Takashi Suzuki

Takashi Nakagawa

Kuninori Tai

Makoto Sakamoto

Seiji Akamatsu

Michinori Tanaka

Koichi Yasumura

Keizo Kan

Noriaki Takemura

Yasuo Yanagihara

Yutaka Kojima

Keisuke Miyajima

Tae Fukushima

Hideki Takasu

Kazuhisa Sugiyama

Takuya Shitsuta

Mitsuhiro Okuno

Naoto Ohi

Takeshi Kodama

Kunihiko Kiyono

Hitoshi Nagao

Hironori Tsutsui

Shuji Matsumura

Hideaki Satou

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): 

Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-&#x3b1;, and IL-4

The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein Xrepresents a nitrogen atom or a group &#x2014;CH&#x2550;; Rrepresents a group &#x2014;Z&#x2014;R, wherein Z represents a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014;, or the like, and Rrepresents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; Rrepresents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group &#x2014;O&#x2014;, a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014;, a lower alkylene group, or the like; and A represents a group or the like, wherein Rrepresents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and Rrepresents an imidazolyl lower alkyl group or the like.

Aromatic compounds for suppressing the generation of collagen

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) &#x2014;CO&#x2014;B&#x2014; wherein B is a Calkylene group and (ii) &#x2014;CO&#x2014;Ba&#x2014; wherein Ba is a Calkenylene group, and include optical isomers and salts of the compounds.

Thiazole compound and use thereof

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Naruto, Japan

Kenji Watanabe