Shionogi Company Limited

Kenji Tomita

Yoshiyuki Taoda

Makoto Kawai

Toshiyuki Akiyama

Hidenori Mikamiyama

Naoyuki Suzuki

Kenji Morimoto

Minako Mikamiyama

Chika Takahashi

Tsutomu Iwaki

Yoshinori Tamura

Takashi Kawasuji

Kenji Takaya

Kosuke Anan

Masafumi Iwatsu

Shuichi Sugiyama

Masayoshi Miyagawa

Hindenori Mikamiyama

Kazunari Hattori

Chika Kageyama

Azusa Okano

The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.

Substituted polycyclic carbamoyl pyridone derivative prodrug

This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity.

Substituted polycyclic carbamolypyridone derivative

Substituted polycyclic carbamoylpyridone derivative

An object of the present invention is to provide a novel integrase inhibitor. The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.

Pyridone derivative having integrase inhibitory activity

The present invention provides a novel compound having an antiviral action, in particular, an HIV replication inhibiting action, as well as a pharmaceutical composition, in particular, an anti-HIV agent. wherein, a broken line means the presence or absence of a bond; Ris substituted or unsubstituted alkyl etc., Ris substituted or unsubstituted alkyloxy etc.; n isor; Ris a substituted or unsubstituted aromatic carbocyclic group; Ris a hydrogen atom etc.; Ris a substituted or unsubstituted aromatic carbocyclic group etc.; Y is a single bond etc.; Ris substituted or unsubstituted alkyl; Ris &#x2014;Z&#x2014;Retc.; Z is &#x2014;NR&#x2014;CO&#x2014; etc.; Ris substituted or unsubstituted alkyl etc.; Ris a hydrogen atom etc.

HIV replication inhibitor

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Osaka, Japan

Kenji Tomita