Nippon Steel Corporation

Nippon Steel & Sumitomo Metal Corporation

Casio Computer Co., Ltd.

Toyoda Iron Works Co., Ltd.

Toray Industries, Inc.

National Cancer Center

Sumitomo Metal Industries, Inc.

Hitachi-johnson Controls Air Conditioning, Inc.

Adv Antest Corporation

Takenaka Corporation

Kenji Tamura

Junichi Okubo

Kunihiro Yabuno

Kunihiro Yoshida

Koichiro Ishihara

Ken Yoshino

Hiroyuki Kurokawa

Tomohisa Yamashita

Sho Takamoto

Sam Soo Hwang

Mitsutoshi Kano

Masao Hori

Ryusuke Nakano

Yoshiaki Nakazawa

Hitoshi Nobumasa

Satoko Kozono

Hiroko Sudo

Takahiro Ochiya

Junpei Kawauchi

Satoshi Kondou

Nobuyoshi Kosaka

Makiko Ono

Hiroshi Nogami

Kenji Imanishi

Michitaka Yoshida

Katsutoshi Takagi

Samsoo Hwang

Isamu Yoshitake

Makoto Nakanishi

Tomihiko Fukuyasu

Nobutaka Tanimoto

Tadashi Matsui

Yukihiro Ota

Yukihiko Kimura

Masahiro Tamura

Atsushi Okuyama

Atsushi Sakaguchi

Yukinori Ido

Takanori Kato

Takashi Hara

Takashi Yatabe

Kazutaka Asabe

Wataru Hatsuse

Masahito Tasaka

Go Adachi

Kiyoshi Nakayama

Yoshihiro Fujii

Kouichi Sato

Tsutomu Kurokawa

Yoji Ogura

Kazuhiro Ueta

Koji Tsukii

Toru Horiuchi

Hidenori Chino

Yasuhide Nakakuki

Zenya Soma

Kiyoshi Nishihara

Yasuyuki Nii

Masaaki Matsui

Yoshikatu Sigematu

Yooichi Hayashi

Keigo Minatani

It is intended to provide a kit or a device for the detection of breast cancer and a method for detecting breast cancer. The present invention provides a kit or a device for the detection of breast cancer, comprising nucleic acid(s) capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting breast cancer, comprising measuring the miRNA in vitro.

Breast cancer detection kit or device, and detection method

A support beam includes a first supporting portion, a second supporting portion, and an arm connecting the first supporting portion to the second supporting portion. The arm includes a web and a flange. The flange includes a first end, a second end, and a center portion. The center portion of the flange is connected to an end of the web. The flange includes bent portions at which the center line of the thickness of the flange is bent outward in the extending direction of the web in the region between the first end and the second end in a transverse cross section of the arm.

Support beam

In a pressing step, a first forged product is pressed by a first die, and thereby, a second forged product including a rough flange having a thickness-changing portion is produced. The thickness-changing portion includes a front part protruding frontward from a side of a rough web part and a rear part protruding rearward from the side of the rough web part. Each of the front part and the rear part includes a first part, and a second part that is thicker than the first part and is located farther from the rough web part than the first part. In the pressing step, at least a part of the rough flange that is above or below the web part (thick part) is pressed by the first die, whereby the material of the first forged product in the part is caused to flow frontward and rearward, and the thickness-changing portion is formed.

Front axle beam and production method thereof

The production method disclosed is a method for producing a front axle beam. The production method includes a die forging step and a bending step. The die forging step is a step of forging a steel material with dies to produce a forged product including a rough web part, which is to be formed into a web part, and four plate-shaped rough flange parts protruding frontward and rearward from an upper side and a lower side of the rough web part, respectively. The bending step is a step of pressing at least one specified rough flange part, which is at least one of the four rough flange parts, with a first die to form a bent portion in the specified rough flange part such that the bent portion is bent inward in an up-down direction of the forged product.

Provided is a production method, including a first preforming process for obtaining a first preform from a billet, a second preforming process for obtaining a final preform from the first preform, and a finish forging process for forming the final preform into a finishing dimension of a forged crankshaft. In the first preforming process, a plurality of flat parts are formed by pressing pin-corresponding parts and journal-corresponding parts in a direction perpendicular to an axial direction of the billet. The second preforming process includes: a process of pressing regions to be a plurality of journals with a width direction of the flat part as a pressing direction by using a pair of first dies; and a process of, after starting pressing by the first dies, decentering regions to be a plurality of pins with the width direction of the flat part as a decentering direction by using second dies.

Method for producing forged crankshaft

Provided is a production method, including a first preforming process, a second preforming process, and a finish forging process. In the first preforming process, while a plurality of flat parts are formed, a region to be a second pin is decentered. The second preforming process includes: a process of pressing each region to be a plurality of journals in a pressing direction corresponding to a width direction of the flat part by using a pair of second dies; and a process of, after starting the pressing by the second dies, decentering a region to be a first pin and to be disposed in a first position and a region to be a third pin and to be disposed in a third position from each other in opposite directions with a width direction of the flat part being as a decentering direction by using third dies.

Disclosed is a method for producing a forged crankshaft. This production method includes: a pressing step of pressing a part in a longitudinal direction (first region) of a bar-like member with a pair of first dies, thereby decreasing a cross sectional area of the first region; and a decentering step of decentering a second region of the bar-like member with a second die with the first region being held. The second region is at least a part of the region of the bar-like member excepting the first region. The decentering direction by the second die is a direction perpendicular to each of the pressing direction by the first dies and the longitudinal direction of the bar-like member.

A crankshaft includes a plurality of journals, a plurality of pins, and a plurality of crank arms. The journals are coaxially disposed with the rotational center of the crankshaft. The pins are decentered with respect to the journals. Each of the crank arms is disposed between one journal and one pin to join the one journal with the one pin. One or more of the crank arms integrally include a counterweight. The counterweight includes two side surfaces. An added layer of a material different from that of a crankshaft body is provided on each of side surfaces of the counterweight. When the Young's modulus of the added layer is E and the Young's modulus of the material of the crankshaft body is E0, E/E0 is 0.2 to 0.4.

Crankshaft

A forged crankshaft manufacturing apparatus processes a forged blank with no flash. The forged blank includes at least one rough crank arm having an excess portion protruding from an outer periphery of a side portion thereof. The manufacturing apparatus includes a first die and a second die paired with each other, a retaining device, and a moving device. The first die and the second die bend or crash the excess portion. The retaining device retains at least one of the rough journals or at least one of the rough pins such that a rough pin decentering direction is perpendicular to a reducing direction in which the first die and the second die apply force for reduction. The moving device supports the retaining device such that the retaining device is movable in the reducing direction.

Apparatus and method for manufacturing forged crankshaft

An apparatus for manufacturing a forged crankshaft includes a pair of upper and lower dies and a first tool. The pair of dies deforms first excess portions and thereby thickens both side portions of a rough crank arm, in a region near a rough pin adjacent thereto. The first tool is fitted in an open space made in the pair of dies, and is capable of coming into contact with a rough-journal-facing surface of the rough crank arm, except the side portions in the region near the adjacent rough pin. The first pair of dies and the first tool have first guides to guide the first tool from a retracting position to a contacting position. The first guides include a first guide disposed on at least one of an upper surface and a lower surface of the first tool.

Apparatus for manufacturing forged crankshaft

A production method includes a preforming process, a forming process and a finish forging process. In the preforming process, an intermediate preform is formed from a billet. In the forming process, while each of a plurality of rough journals of the intermediate preform is held and pressed vertically by a pair of holding dies, rough pins are decentered in directions perpendicular to the pressing direction by the holding dies and an axial direction of the intermediate preform, and the intermediate preform is pressed in the axial direction of the intermediate preform. In the finish forging process, a final preform is placed such that the directions in which the rough pins are decentered are parallel to a horizontal direction, and the thus placed final preform is pressed vertically by a pair of pressing dies. The production method reduces the risk of occurrence of seams on a forged crankshaft.

A boosting operation of a converter and the intermittent energization operation of an inverter are optimally performed in accordant with input or output. The power converter includes the converter capable of boosting a DC voltage outputted by switching operation alternately performing shorting and rectification; the inverter; an inverter capable of performing intermittent energization in which switching around zero cross of a motor current is turned off upon converting the DC voltage outputted by the converter into three-phase AC power; and a controller that controls the converter to perform boosting operation and the inverter to perform the boosting operation of the converter and the intermittent energization operation of the inverter linkingly.

Power converter and refrigeration air conditioner

Growing community of inventors

Takatsuki, Japan

Kenji Tamura