Toyama Chemical Co., Ltd.

Kenji Takeda

Isamu Saikawa

Hiroyuki Imaizumi

Takihiro Inaba

Hiroshi Sadaki

Yasuo Watanabe

Ryuko Takeno

Joji Nakano

Shinzaburo Minami

Isao Myokan

Toru Hiraiwa

Seishi Morita

Tetsuya Kajita

Takashi Nagai

Hiroyo Kawafuchi

Yoshikazu Fukuoka

Makoto Takata

Kunikazu Furuhata

Isao Watanabe

Hisashi Minami

Nobuo Terashima

Tadakazu Takakura

Mineichi Sudani

Toyokazu Kobayashi

1,2-benzoisoxazole derivative or its salt and brain-protecting agent

A piperazine derivative represented by the following formula or a salt thereof: ##STR1## which is useful for curing cerebro-vascular disease and post-cerebro-vascular disease.

Piperazine derivative or its salt, process for producing the same and

This invention relates to a 7-amino-3-(pyrazinylmethyl)- or (pyridazinylmethyl)-cephalosporins of the formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl-protecting group; R.sup.2 represents a group of the formula: ##STR2## in which R.sup.6 represents a hydrogen atom, a C.sub.1-5 alkyl group or a di-C.sub.1-5 alkylamino group; R.sup.13 represents a C.sub.1-5 alkyl group; and R.sup.28 represents an amino group.

7-amino-3-(pyrazinylmethyl) or (pyridazinylmethyl)-cephalosporins

This invention relates to a novel process for producing a 2-(2-aminothiazol-4-yl)glyoxylic acid derivative or a salt thereof which are useful in producing a cephalosporin antibiotic, and to intermediates for said derivative and salt and a process for producing the intermediates.

Novel process for producing 2-(2-aminothiazol-4-yl)glyoxylic acid

The invention relates to antibiotic compounds of the formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl-protecting group; R.sup.2 represents a group of the formula: ##STR2## R.sup.3 represents a hydrogen atom or an alkoxy group; R.sup.4 represents a hydrogen atom or a halogen atom; R.sup.5 represents a hydrogen atom or a protected or unprotected amino group; A represents a group of the formula, --CH.sub.2 -- or a group of the formula, ##STR3## or a group of the formula, ##STR4## and the bond  means that the compound may be a synisomer or an anti-isomer or a mixture thereof.

Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl)

Process for producing 2-(2-aminothiazol-4-yl)glyoxylic acid derivative

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Toyama, Japan

Kenji Takeda