Eisai Company, Limited

Kenji Tai

Hiroyuki Yoshimura

Shigeki Hibi

Katsuya Tagami

Mitsuo Nagai

Kouichi Kikuchi

Takayuki Hida

Shinya Abe

Takashi Yamanaka

Ieharu Hishinuma

Junichi Nagakawa

Makoto Asada

Norimasa Miyamoto

Seiko Higashi

Aichi Ogasawara

Seiichi Kobayashi

Yasushi Okamoto

Takashi Sato

Makoto Okita

Naoki Kobayashi

Naoki Tokuhara

Yumiko Nagasaka

Mono- or polyenic carboxylic acid derivatives

Carboxylic acid derivatives having fused rings

To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic compounds represented by the general formula (1-I) or physiologically acceptable salts thereof:

Fused-ring carboxylic acid derivatives

The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ##STR2## represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR3## [wherein R.sup.k (k: 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR4## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.

Compounds of the formula and compounds of the formula ##STR1## or their salts have the potent ability to bind to retinoic acid receptors thus useful in treating psoriasis and rheumatoid arthritis.

Mono-or polyenic carboxylic acid derivatives

Growing community of inventors

Ibaraki, Japan

Kenji Tai