Other

Lintec Corporation

Nisshin Flour Milling Co., Ltd.

Freund Industrial Co., Ltd.

Toko Yakuhin Kogyo Co., Ltd.

Kenji Sugibayashi

Yasunori Morimoto

Masatoshi Suzuki

Seiichi Umeda

Kiyoshi Sato

Kouji Kobayashi

Masao Ueno

Tomio Hatanaka

Rui Saito

Kiyose Nakagawa

Hisashi Kusano

The present invention provides a percutaneous absorption system and a percutaneous absorption method, which have a simple constitution and can realize the easy and continuous percutaneous absorption of medicine even when the medicine is formed of a water-soluble oligomer solution or a high-molecular solution. In the percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine therein and a support portion for supporting the medicine reservoir portion, the support portion including an adhesive layer and a substrate having medicine non-permeating property, the system is provided with an elastic member for applying pressure to the medicine held in the inside of the medicine reservoir portion, and by breaking the substrate having medicine non-permeating property in the support portion using a mechanical stimulus such as an injection needle or the like, the medicine is released (delivered) at a fixed rate.

Percutaneous absorption system and percutaneous absorption method

An adhesive patch for percutaneous delivery of isosorbide dinitrate includes a piece of separating paper; a percutaneous salve preparation which is solvent free and which is comprised of: (a) isosorbide dinitrate; (b) a percutaneous absorption accelerator which is at least one substance selected from the group consisting of a chained monocarboxylate and a higher alcohol; and (c) a tackifier composition as an additive, wherein the chained monocarboxylate is selected from the group consisting of isopropyl palmitate, isopropyl myristate, cetyl lactate, diethyl sebacate, xylol laurate, cetyl isooctanoate and lauryl lactate, wherein the higher alcohol is selected from the group consisting of cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol and myristyl alcohol, and wherein the percutaneous absorption accelerator is present in an amount ranging between 3 and 12 wt % if a chained monocarboxylate is used and between 1 and 3 wt % if a higher alcohol is used; and a surface coating material which is polymeric.

Adhesive patch for percutaneous delivery of isosorbide dinitrate

Percutaneously absorbable compositions of morphine or analogous

Percutaneous or trans-mucosal absorption enhancer comprising of a terpeneketone and preparation containing thereof. Preferably, the preparation contains a percutaneous or trans-mucosal absorption enhancer in an amount of 0.01-20 weight % of the preparation. In preparing the preparation, a terpeneketone is dissolved and emulsified in a water soluble organic solvent which is medically allowable.

Percutaneous or trans-mucosal absorption enhancers, preparations

The transdermal penetration of N-(2-hydroxyethyl) nicotinamide nitrate useful for the treatment of angina pectoris is improved by the use of a mixed solvent comprising an alcohol of 2 to 7 carbon atoms and an aliphatic ester having a molecular weight of at least 180 in the formulation of the external preparations.

Nicorandil containing external preparations

Growing community of inventors

Sakado, Japan

Kenji Sugibayashi