Rational Drug Design Laboratories

Astellas Pharma Gmbh

Yamanouchi Pharmaceutical Company Ltd.

Kenji Sudo

Akio Kamikawa

Wataru Hamaguchi

Hiroshi Suzuki

Junji Miyata

Toru Kontani

Tomoaki Kawano

Shiro Shigeta

Tomoyuki Yokota

Tsuyoshi Kajiyashiki

Wataru Watanabe

Ryu Sato

Koji Chono

There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. An N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.

Amide derivative

A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-{2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.

Tetrahydro-2H-thiopyran-4-carboxamide derivative

Antiviral agent containing benzodithiin derivative as active ingredient

Growing community of inventors

Chuo-ku, Japan

Kenji Sudo