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Chugai Seiyaku Kabushiki Kaisha

Takara Shuzo Co., Inc.

Kenji Sobue

Keiichi Nagai

Takao Isogai

Koji Hayashi

Tetsuo Nishikawa

Toshio Ota

Shin-Ichi Funahashi

Ai Wakamatsu

Tomoyasu Sugiyama

Shizuko Ishii

Shoji Miyata

Tetsuji Otsuki

Jun-Ichi Yamamoto

Kaoru Otsuka

Ikunoshin Kato

Kiyozo Asada

Hirokazu Kotani

Takashi Hashida

Ken'ichiro Hayashi

A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene 'C-NT2RP3001495' was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.

Antibody directed to protein involved in maintaining differentiation of smooth muscle cells

Genes associated with the maintenance of differentiation of smooth muscle cells

Provided are functional peptide fragments of human caldesmon having calmodulin and actin-binding activity, the amino acid sequences and nucleic acid sequences therefor.

DNA encoding a protein comprising calmodulin-and actin-binding human

Proteins comprising calmodulin- and actin-binding human caldesmon

Growing community of inventors

Osaka, Japan

Kenji Sobue