Nippon Shinyaku Company, Ltd.

Other

Kenji Sempuku

Hiromu Murai

Katsuya Ohata

Hiroshi Enomoto

Yoshiaki Yoshikuni

Yukio Fujita

Koji Kitaguchi

Kohei Kura

Tamiki Mori

Yasuo Yasutomi

Tadaaki Ohgi

Katsuhide Saito

Yoshihisa Shibata

Yoshiaki Aoyagi

Fusao Ueda

Katsahide Saito

Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen, hydroxy, halo, alkoxy of 1 to 4 carbon atoms or aralkyloxy of 1 to 4 carbon atoms and X and Y are each hydrogen or nicotinoyl are useful as anti-edema agents, anti-inflammatories, analgesics, anti-pyretics, anti-allergenics and anti-thrombosis agents.

Triazine derivatives to treat pain, fever, inflammation, allergies and

Triazine derivatives

A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:

Abietamide derivatives, their production and use

The mono-, bis- and trisnicotinoyl derivatives of melamine and the corresponding mono- and bisnicotinoyl derivatives of benzoguanamine demonstrate anti-ulcer and diuretic activity. A representative embodiment is 2-nicotinamido-4,6-diamino-s-triazine.

Nicotinamido-s-triazines

Process for the preparation of abietanilides which comprises reacting abietic acid, dihydroabietic acid, tetrahydroabietic acid or a reactive derivative thereof with aniline and the products thereby produced, compositions containing the same for reducing blood serum cholesterol and method of use of such compositions.

Abietanilides, their production and use

Substituted N-phenyl and N-benzyl abietamide derivatives, including the dehydro-, dihydro-, and tetrahydroabietamide derivatives, are cholesterol lowering agents. The abietamide derivatives, of which N-(2,6-dimethylphenyl)-.DELTA..sup.8 -dihydroabietamide is a typical example, are produced by the reaction of abietic acid, dehydroabietic acid, dihydroabietic acid, tetrahydroabietic acid and/or active derivatives thereof with a substituted aniline or benzylamine.

N-(substituted phenyl and benzyl)abietamides

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Suita, Japan

Kenji Sempuku