Nof Corporation

The University of Tokushima

Kenji Sakanoue

Yuji Yamamoto

Hiroshi Kikuchi

Tohru Yasukohchi

Chika Itoh

Syunsuke Ohashi

Ken-ichiro Nakamoto

Hiroki Yoshioka

Kouzoh Sanchika

Kazuhiro Kubo

Tatsuhiro Ishida

Syunsuke Ohhashi

Kenichiro Nakamoto

Tomohiro Shirosaki

Ken-Ichiro Nakamoto

Hiroshi Kiwada

Chika Ito

A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OAand OAare each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OAare the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds,

Polyalkylene glycol derivative and modified bio-related substance

An object of the present invention is to provide a novel multibranched polyoxyalkylene derivative, and an intermediate for the production thereof. Specifically, the object is to provide a multibranched polyoxyalkylene derivative which can keep a high activity of a bio-related substance modified with the multibranched polyoxyalkylene derivative and which can easily produce the modified substance; an intermediate thereof; and a bio-related substance to which the multibranched polyoxyalkylene derivative is bonded. The novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (1) having a functional group reactive with a bio-related substance and the bio-related substance according to the invention has a structure modified with the above polyoxyalkylene derivative (1) by a reaction. Furthermore, the intermediate for the production of the novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (A). wherein AO and AO independently represent an oxyalkylene group having 2 to 4 carbon atoms, m represents 20 to 500, n represents 15 to 700, R represents a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, X represents a functional group reactive with a bio-related substance, and Xrepresents a hydroxyl group which may be protected.

Multibranched polyoxyalkylene derivative

A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OAand OAare each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OAare the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

Modified bio-related substance, process for producing the same, and intermediate

A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various physiologically active substances according to the object is provided. 

Polyoxyalkylene derivative

A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OAis an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OAare the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance,

A polyoxyalkylene derivative is represented by formula (I):wherein Z represents a residue of a compound having 2 to 8 hydroxyl groups; AO represents an oxyalkylene group having 2 to 18 carbon atoms; n and m each represent an integer of 0 to 2000 provided that both n and m do not represent 0; a and b each represent an integer satisfying the relationships: 2&#x2266;a+b&#x2266;8 and 1&#x2266;b; R represents a hydrocarbon group having 1 to 30 carbon atoms; and X represents a divalent hydrocarbon group having 3 to 10 carbon atoms.

Polyoxyalkylene derivative and process of producing the same

Polyethylene glycol and process for producing the same

Growing community of inventors

Kanagawa, Japan

Kenji Sakanoue