Kyowa Hakko Kogyo Co., Ltd.

Kenji Ohmori

Fumio Suzuki

Takeshi Kuroda

Haruhiko Manabe

Yoshisuke Nakasato

Hidee Ishii

Akira Karasawa

Kazuhiro Kubo

Tadafumi Tamura

Akio Ishii

Hiroyuki Obase

Etsuo Oshima

Soichiro Sato

Katsuichi Shuto

Ichiro Miki

Shigeto Kitamura

Hiroshi Nakajima

Takashi Kawakita

Junichi Shimada

Etsuo Ohshima

Tetsuji Ohno

Michio Ichimura

Kyoichiro Iida

Koji Yanagawa

Tohru Matsuzaki

Rie Koike

Hisashi Hosoe

Hiroshi Tanaka

Tatsuya Tamaoki

Shizuo Shiozaki

Hiroshi Takizawa

Toshikazu Kamiya

Toshiaki Kumazawa

Yoshimasa Oiji

Masatoshi Yamato

Hiroaki Hayashi

Yoshikazu Miwa

Hiroshi Tsumuki

Kuniko Hashigaki

Yoshisuke Nakazato

Kazuihiro Kubo

Shizuo Otaki

Ikufumi Yoshitake

Derivatives of benzofuran or benzodioxazole compounds

Derivatives of benzofuran or benzodioxole

Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R.sup.1 represents lower alkyl or substituted or unsubstituted aryl; and

Imidazonaphthyridine derivatives

Pyrazolothiazolopyrimidine derivatives

Tetracyclic compounds

Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

Tricyclic thromboxane A.sub.2 antagonists

Disclosed is a pyrazolonaphthyridine compound represented by the formula: ##STR1## wherein R.sup.1 is represents hydrogen, lower alkyl, aralkyl, or substituted or unsubstituted aryl, R.sup.2 represents hydrogen, lower alkyl, thienyl, substituted or unsubsutituted aryl, hydroxy or amino, or a pharmaceutically acceptable salt thereof. The compound possesses antiinflammatory effect, immunosuppressive effect, broncho-dilatory effect and hair growth-stimulative effect.

Condensed naphthyridine derivatives

There are disclosed condensed purine derivatives represented by formula; ##STR1## in which R.sup.3 represents hydrogen, lower alkyl or benzyl; each of X.sup.1 and X.sup.2 independently represents hydrogen, lower alkyl, aralkyl or phenyl; and n is an integer of 0 or 1; R.sup.1 represents hydrogen, lower alkyl, alicyclic alkyl, noradamantan-3-yl, dicyclopropylmethyl or styryl; and R.sup.2 represents hydrogen, lower alkyl or alicyclic alkyl; or a pharmaceutically acceptable salt thereof. The derivatives and pharmaceutically acceptable salts are useful as diuretics, renal protecting agents, antiallergic agents and hypotensives.

Condensed purine derivatives

Disclosed is a thienopyridine derivative represented by formula (I): ##STR1## wherein one of A and B represents --S-- and the other represents --CH.dbd.; R represents hydrogen or lower alkyl, and Z represents pyridyl; or a pharmaceutically acceptable salt thereof. The thienopyridine derivative is useful as an immunoregulator and for the prevention and treatment of osteoporosis.

Thienopyridine derivatives

A pyrazoloquinoline derivative having the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent a hydrogen atom or a lower alkyl group; R.sup.4 represents a hydrogen atom, a lower alkyl group, a halogen-substituted lower alkyl group, or a lower alkoxycarbonyl group; the dotted line means that the pyrazole ring has two conjugated double bonds; and R.sup.4 is bonded to the nitrogen atom at the 1-position or 2-position, or pharmacologically acceptable salts thereof. These compounds exhibit excellent anti-inflammatory activity and hepatic insufficiency treating activity.

Pyrazoloquinoline derivatives

There are disclosed s-triazolo[3,4-i]purine derivatives represented by formula: ##STR1## wherein Y-Z represents ##STR2## R.sub.4 represents hydrogen, alkyl, substituted or unsubstituted aromatic heterocyclic group or substituted or unsubstituted aryl; and X.sup.2 represents oxygen, sulfur or NH; each of R.sup.1 and R.sup.2 independently represents hydrogen, alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; R.sup.3 represents alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; X.sup.1 represents oxygen or sulfur; and  represents a single bond or a double bond or pharmaceutically acceptable salts thereof.

s-Triazolo(3,4-I)purine derivatives

Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic acitvity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

Disclosed is a novel arylalkylamine derivative represented by the formula (I) ##STR1## wherein X represents --O--, --CH.sub.2 -- or --NR.sup.3 -- in which R.sup.3 represents hydrogen or lower alkyl;

Arylalkylamine derivatives

Growing community of inventors

Mishima, Japan

Kenji Ohmori