Shimano Inc.

Shionogi Company Limited

Hokkaido University

Kikkoman Corporation

Kenji Nakahara

Toshio Tetsuka

Tsuyoshi Hasegawa

Kouki Fuchino

Genta Tadano

Ken-ichi Kusakabe

Syuhei Yoshida

Etsuyoshi Watarai

Yoshiyuki Taoda

Takuji Masui

Seiji Fukui

Chikara Masuta

Yuki Tachibana

Shigeru Ando

Yuto Unoh

Hiroki Atarashi

Yukiko Yamatsu

Michihito Sasaki

Tetsuya Yamada

Shota Uehara

Koji Kasamatsu

Takahiro Suto

Atsuhiro Iimuro

The present invention provides a compound exhibiting coronavirus 3 CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. A compound represented by Formula: or a pharmaceutically acceptable salt thereof.

Triazine derivatives having virus replication inhibitory activity and pharmaceutical composition comprising the same

An object of the present invention is to provide a cucumber mosaic virus (CMV)-resistant solanaceous plant. The present invention provides a CMV-resistant solanaceous plant having a mutated eIF4E gene encoding an eIF4E protein nonfunctional for CMV. In addition, the present invention provides a method for producing a CMV-resistant plant, the method comprising mutating an eIF4E gene of a solanaceous plant into a mutated eIF4E gene encoding an eIF4E protein nonfunctional for CMV.

Virus-resistant plant and method for producing the same

The present invention provides a compound which has an effect of inhibiting amyloid &#x3b2; production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid &#x3b2; proteins. A compound of the formula (I): wherein X is &#x2014;C(R)(R)&#x2014;, &#x2014;C(R)(R)&#x2014;C(R)(R)&#x2014; or &#x2014;C(R)&#x2550;C(R)&#x2014;, Ris substituted or unsubstituted alkyl or the like,

Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity

The present invention provides a compound which has an effect of inhibiting amyloid &#x3b2; production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid &#x3b2; proteins. A compound of the formula (I): 

A hydraulic connector arrangement includes a shaft member, a banjo fitting, a pair of sealing members and a banjo fixing member. The shaft member has a hydraulic passageway and an opening that extends from the hydraulic passageway to an outer surface of the shaft member. The banjo fitting rotatably extends around the shaft member covering the opening. The pair of sealing members are disposed between the shaft member and the banjo member and on opposite sides of the opening. The banjo fixing member is coupled to the shaft member to retain the banjo fitting to the shaft member. Further, the banjo fixing member is dimensioned to allow rotation of the banjo relative to the shaft member and the banjo fixing member.

Hydraulic connector arrangement

An apparatus for a bicycle brake comprises a housing with a first piston bore and a second piston bore, a first piston disposed in the first piston bore, a first piston rod attached to the first piston and extending from the first piston toward the outside of the housing for coupling to a first brake arm, and a second piston disposed in the second piston bore. The first piston moves along a first piston axis, and the second piston moves along a second piston axis.

Hydraulic caliper brake for a bicycle

An apparatus for a bicycle brake comprises a housing with a first piston bore, a first piston disposed in the first piston bore, and a first piston rod fixedly attached to the first piston and extending from the first piston toward the outside of the housing. The first piston rod includes a first brake arm coupling portion for coupling to a first brake arm, and an adjustment mechanism adjusts a distance of the first brake arm coupling portion relative to the piston.

Quick-release apparatus for a bicycle hydraulic caliper brake

A bicycle hydraulic brake actuation device includes a hydraulic master cylinder housing having a bore, a lever, a master piston and an adjuster. The lever is pivotally coupled to the hydraulic master cylinder housing for movement between an at rest position and a brake engagement position. The master piston is disposed within the bore and having an adjustment end. The adjuster is operably disposed between the adjustment end of the master piston and a portion of the lever. The adjuster is movable between a plurality of adjustment positions relative to the adjustment end such that with the lever in the at rest position, movement of the adjuster between the plurality of adjustment positions moves the master piston between a corresponding plurality of adjustment positions along an axial length of the bore.

Bicycle hydraulic brake actuation device

A device to mount a control lever to a bicycle handlebar includes a bracket, an expanding bolt, and a fixing member. The bracket is configured to be connected to the control lever and includes an inlet opening with a center axis, a first tapered portion extending along an axial direction, and at least one tapered outer serration formed on the first tapered portion. The expanding bolt includes a tubular portion and a second tapered portion extending along the axial direction. The tubular portion includes an outer threaded surface. The fixing member is disposed on the tubular portion of the expanding bolt. The first and second tapered portions are configured to operate so as to push the fixing member against an inner surface of the bicycle handlebar when the device is mounted to the bicycle handlebar.

Device to mount control lever to bicycle

A bicycle hydraulic brake device includes a housing having a master cylinder, a master piston movably mounted in the master cylinder, a brake operating member and an adjustment mechanism. The brake operating member is arranged to move between a rest position and a brake actuating position and to move the master piston in response to movement of the brake operating member to the brake actuating position. The adjustment mechanism is arranged to adjust the rest position and a free stroke of the brake operating member with an initial travel position of the master piston remaining unchanged. The adjustment mechanism includes a first adjustment member that adjusts a length of a free stroke and a second adjustment member that adjusts the rest position of brake operating member without changing the length of the free stroke.

Growing community of inventors

Osaka, Japan

Kenji Nakahara