Kyowa Hakko Kogyo Co., Ltd.

Kenji Muto

Nobuhiro Nakamizo

Minoru Watanabe

Tokuyuki Kuroda

Toru Sugaya

Tamotsu Hashimoto

Yoshinori Takemoto

Takao Hatta

Koji Yamada

Akira Karasawa

The compound of the formula ##STR1## is disclosed to have a less rapid decrease in blood pressure in its use as an antihypertensive.

1-benzyl-3,5-dimethyl-4-piperdyl ester of a Hantzsch dihydropyridine

An optical isomer having an optical rotation degree of (+) from among (.+-.)-.alpha.-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dica rboxylic acid-3-(1-benzyl-3-piperidyl) ester-5-methyl ester, the hydrochloride of which has melting points ranging from 196.degree. to 202.degree. C.; or a salt thereof is described as being suitable for use in a pharmaceutical composition having hypotensive activity.

1,4-Dihydropyridine derivatives

A vasodilating or anti-hypertensive composition comprises a pharmaceutical carrier and an effective amount of a 1,4-dihydropyridine compound as an active ingredient. The 1,4-dihydropyridine compound may be represented by the following general formula: ##STR1## wherein R'.sub.1 and R'.sub.4 represent a hydrogen atom, R'.sub.2 and R'.sub.3 represent an alkyl group having 1-5 carbon atoms or a substituted heterocyclic group wherein a substituent is an N-benzylpiperidyl group, R'.sub.5 represents a nitro group, and R'.sub.6 and R'.sub.7 represent an alkyl group having 1-5 carbon atoms.

1-Substituted 1,4-dihydropyridines

Compounds having coronary and vasodilator effects, a hypotensive effect, and useful as antianginal drugs and drugs for treating hypertension are represented by the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different groups and each represents a lower alkyl group, one of R.sub.3 and R.sub.4 represents a lower alkyl group and the other represents a group of the general formula: ##STR2## wherein R.sub.5 represents an aralkyl group or an acyl group and n represents 0 or an integer of 1-3; the pharmaceutically acceptable acid addition salts thereof are also effective therapeutic compounds.

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Shizuoka, Japan

Kenji Muto