Sanyo Electric Co., Ltd.

Matsushita Electric Industrial Co., Ltd.

Daiichi Sankyo Company, Limited

Panasonic Corporation

Omron Corporation

Nippon Sheet Glass Company, Limited

The Kansai Electric Power Co., Inc.

Nissin Electric Co., Ltd.

Cardinal Cg Company

Kenji Murata

Yasuo Kishi

Hiroshi Inoue

Daisuke Nomasaki

Naohiro Takemoto

Norihito Murayama

Chikaomi Yamada

Hiroyuki Tanaka

Akira Matsuzawa

Keiichi Kusumoto

Yoshinori Miyada

Michiyo Yamamoto

Shinichi Kouzuma

Jun Watanabe

Takayuki Baba

Kenji Yoshikawa

Noriyasu Haginoya

Yoshiko Kagoshima

Masashi Numata

Taeko Shinozaki

Masashi Morizane

Masakazu Shigemori

Ryutaro Kanada

Kosuke Uemura

Kenta Yamakawa

Tomoaki Hamada

Eri Tokumaru

Mayumi Kitagawa

Akiko Kurimoto

Machiko Shiroishi

Yutaka Terada

Keisuke Tanaka

Koji Oka

Tsuyoshi Ebuchi

Toshio Yagiura

Hideki Tanaka

Koji Sushihara

Junichi Naka

Yoshitsugu Inagaki

Kazuhiro Doshita

Hidemi Nakai

Takayoshi Yasuda

Susumu Ito

Youichi Okamoto

Nobuyuki Nishi

Tokuo Emura

Kazuya Hatooka

Koichi Okada

Toshiaki Kitazoe

Kazuo Sonohara

Kyoji Ishizu

Katsuhisa Enjouji

Hiroshi Ikeizumi

Syozaburo Nishikawa

Yoichi Okamoto

The present invention provides a compound or a pharmaceutically acceptable salt thereof having an inhibitory action on the interaction between menin and an MLL protein. The compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. wherein, in the formula (1), the dotted circle, R, R, R, R, R, R, R, R, Ring Q, W, m and n are each as defined in the description.

Cycloalkane-1,3-diamine derivative

A fixture includes a base portion and a pair of holding portions on the base portion. Each holding portion include a clamping portion for clamping an object, and a head portion on the clamping portion side opposite to the base portion side. Each head portion includes a through-hole for a fastening member for adjusting a gap between the holding portions. The rigidity of the clamping portions is smaller than the rigidity of the head portions, with respect to deformation caused by the fastening member. The distance from the base portion to end portions of the holding portions in a plane orthogonal to the axial direction of the object is determined according to the tolerance prescribed for the object. The gap when external force is not being applied by the fastening member is determined according to an allowable amount of stress to be applied to the object.

Fixture

An optical sensor includes a case and an integrated light projector entirely within the case including a light emitter, a light projecting lens, and a light projecting lens holder configured to hold the light projecting lens. A light receiver of the optical sensor is configured to receive reflected light of light projected from the light projector, and a light receiver lens is configured to form an image of the reflected light on the light receiver. The light projector, the light receiver, and the light receiver lens are each independently and directly fixed to the case.

Optical sensor

To provide an optical sensor that can ensure accuracy of positions of a light projecting unit and a light receiving unit in a case. The optical sensor includes a case, an integrated light projecting module that includes a light emitting unit and a light projecting lens, a light receiving unit configured to receive reflected light of light projected from the light projecting module, and a light receiving lens unit configured to form an image of the reflected light on the light receiving unit. The light projecting module, the light receiving unit, and the light receiving lens unit are each independently and directly fixed to the case.

Compounds of Formula (I) promote axonal outgrowth angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases, peripheral arterial occlusive diseases, or after-effects of these diseases. in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R, Rand Rare each independently a hydrogen atom, an alkyl group, or an amino group; E is an oxygen atom or an &#x2014;NRgroup (wherein Ris an alkyl group or the like); n is an integer of 0 to 5; X and Y are each a connecting bond, a cycloalkyl group, or &#x2014;CO&#x2014;; and Q is a hydrogen atom or a phenyl group.

Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same

Compounds of Formula (I) promote axonal outgrowth angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases, peripheral arterial occlusive diseases, or after-effects of these diseases. in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R, Rand Rare each independently a hydrogen atom, an alkyl group, or an amino group; E is an oxygen atom or an &#x2014;NRgroup (wherein Ris an alkyl group or the like); n is an integer of of 0 to 5; X and Y are each a connected bond, a cycloalkyl group, or &#x2014;CO&#x2014;; and Q is a hydrogen atom or a phenyl group.

Provided is a compound that has the ability to promote axonal outgrowth in combination with the ability to promote angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases such as myocardial infarction and organic angina, peripheral arterial occlusive diseases such as critical limb ischemia, or after-effects of these diseases. Specifically, the compound is represented by the following formula (I): in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R, Rand Rare each independently a hydrogen atom, an alkyl group, an amino group or the like; E is an oxygen atom or an &#x2014;NRgroup (wherein Ris an alkyl group or the like); n is an integer of 0 to 5; X and Y are each a connecting bond, a cycloalkyl group, &#x2014;CO&#x2014; or the like; and Q is a hydrogen atom or a phenyl group.

A clock and data recovery circuit includes a multiphase clock generator circuit which generates a multiphase clock having a plurality of clocks, a sampling circuit which samples a received data signal transferring serial data in synchronism with each of the plurality of clocks, and generates a plurality of data signals, a data recovery unit which generates a selection signal indicating a data signal having an appropriate phase among the plurality of data signals, and a storage unit which stores the selection signal. The data recovery unit selects one of the plurality of data signals, based on the selection signal read from the storage unit, and a clock corresponding to the selected data signal.

Clock and data recovery circuit

A spread spectrum controller () controls a PLL () so that the PLL outputs a spread-spectrum processed clock signal. A loop bandwidth controller () controls at least one of a phase detector (), a loop filter (), a voltage-controlled oscillator (), and a frequency divider () in the PLL () during operation of the spread spectrum controller () to change a loop bandwidth of the PLL ().

Spread spectrum clock generation device

An external input operation clock signal is required for operating a conventional A/D converter, and the performance of the A/D converter is undesirably determined by the characteristics of the external input operation clock. A clock generator circuit for automatically generating an operation clock is provided inside an A/D converter to make the A/D converter require no external input operation clock. Further, a circuit for detecting the operation times of the constituents of the A/D converter is provided to generate a clock with which the A/D converter is optimally operated, thereby realizing high-speed operation and low power consumption.

A/D converter

The conventional A/D converter has a drawback that the conversion precision is degraded when the operation periods of the constituents of the A/D converter are shortened due to the duty ratio of an external input clock because the operation periods of the constituents of the A/D converter depend on the pulse width of the external input clock. However, a highly-precise A/D conversion operation independent of the duty ratio of the external input clock can be realized by providing a circuit for detecting the operation periods of the constituents of the A/D converter, and adjusting the duty ratio of the operation clock according to the detected operation periods of the constituents of the A/D converter.

A semiconductor integrated circuit has a plurality of capacitor cells, and each capacitor cell has an upper electrode and a lower electrode. These electrodes are respectively connected to an upper electrode wiring and a lower electrode. When, for example, the upper electrode is connected to the upper electrode wiring and the electrode wiring is located at a side of the lower electrode of another capacitor cell or a side of the lower electrode wiring connecting these electrodes, a shield wiring is provided between the upper electrode wiring and the adjacently-located lower electrode of the other capacitor cell or between the upper electrode wiring and the adjacently-located lower electrode wiring. Thus, with this shield wiring, the capacitance coupling between each wiring of the capacitor cells and each upper electrode or each lower electrode of the capacitor cells are effectively suppressed.

Semiconductor integrated circuit, D-A converter device, and A-D converter device

In a charge redistribution type A/D converter, an input-side capacitor terminal and a comparator-side capacitor terminal are connected through first and second analog switches to a fixed-voltage supply circuit, and the input-side capacitor terminal is connected through a third analog switch to the outside. Immediately before sampling an analog signal, the first and second analog switches are closed while the third analog switch is opened, according to a RESET signal. Thereby, fixed voltages are supplied to the input-side capacitor terminal and the comparator-side capacitor terminal, respectively, and charge stored in a weighting capacitor unit is initialized to a predetermined value.

A/D converter and A/D conversion method

Growing community of inventors

Osaka, Japan

Kenji Murata