Santen Pharmaceutical Co., Ltd.

Asahi Glass Company, Limited

Kenji Morishima

Mitsuaki Kuwano

Akio Kimura

Hiroyuki Asada

Asuka Kamimura

Takashi Hamano

Norihisa Hatano

Kazufumi Shiotani

Yusuke Momokawa

Kenichi Endo

Masayuki Umeda

A purpose of the present invention is to remove dryness and unpleasantness in eyes of contact lens wearers and to obtain favorable moist feel and wearing feel by stabilizing a lacrimal fluid layer on the surface of eyeballs of the wearers. By using an ophthalmic composition containing polyvinyl pyrrolidone, the lacrimal fluid layer existing on ionic contact lenses can be stabilized via adsorption of polyvinyl pyrrolidone on the ionic contact lenses. By adding a viscosity-increasing agent to the ophthalmic composition, the lacrimal fluid layer can be maintained in a stable state over a long period of time.

System for stabilizing lacrimal fluid layer

A fluorometholone ophthalmic suspension containing fluorometholone as an active ingredient, wherein a cellulosic polymer, such as hydroxypropylmethylcellulose or methylcellulose, and a nonionic surfactant, such as polysorbate 80, are added thereto to increase the redispersibility of the fluorometholone. The amount of the cellulosic polymer is preferably 0.0001 to 0.003 (W/V) %, and the amount of the nonionic surfactant is preferably 0.0001 to 0.5 (W/V) %. The fluorometholone ophthalmic suspension has excellent redispersibility and hardly forms aggregates.

Fluorometholone ophthalmic suspension

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Osaka, Japan

Kenji Morishima