Hisamitsu Pharmaceutical Company, Inc.

Kyodo Printing Co., Ltd.

Kenji Mori

Naruhito Higo

Shuji Sato

Iwao Nozawa

Katsuhiro Nakamura

Tatsuya Ogawa

Saori Takahashi

Yasushi Fuchita

Takeshi Konno

Hiroyuki Maeda

Kazutaka Inoue

Kazuya Katagai

Noriyuki Kuzumaki

The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed. An electrode device () has a protrusion (), which projects upward, in the part of an outward flange section (), other than a recess () formed by molding. The protrusion () is arranged so as to surround an outer periphery of the recess (). When the recess () is cold-pressed, the protrusion () prevents warp (warp waving along a peripheral direction) in the outward flange section () from occurring. Consequently, the protrusion () also eases warp of an electrode layer () extending on the outward flange section () and prevents disconnection of the electrode layer ().

Electrode device having recessed part

The present invention provides an iontophoresis system for non-invasively taking a physiological substance out of the living body, the system being suitably used for the mucous membrane. The present iontophoresis system non-invasively takes a physiological substance out of a living body. The system includes a plurality of electrode structures and a power supply device connected to the electrode structures. At least one of the electrode structures has a physiological substance extraction pad applied to the mucous membrane. In the present system, the time to apply electric energy to the living body by the power supply device is set between 30 seconds and 20 minutes. The physiological substance extraction pad which is provided in the electrode structure is applicable to the mucous membrane of the mouth and can be used, for example, to monitor glucose in the living body or an amount of drug administered.

Iontophoresis system

It is an object of the invention to prevent not only cracking but also blocking of an electrode layerand an electrically insulating layer, particularly the electrically insulating layer, which is formed on a base film. An electrode apparatus comprises a base filmfor defining a recessat the inner periphery of a bending part, and an electrode layerand an electrically insulating layerwhich are pattern formed on the base film. The electrode layercrosses the bending partfrom the inside of the recessto the outside. The electrically insulating layercovers the upper part of the electrode layerin the vicinity of the bending part. A resin composition obtained by admixing a low Tg resin having a glass transition temperature equal to 25 degrees C. or lower and a high Tg resin having a higher glass transition temperature (for example, 40 degrees C. or higher) than that of the low Tg resin is used as a dielectric of the electrically insulating layer

Electrode apparatus for preventing cracking of the electrode and insulating layers

Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent through the skin or mucosa, when placed in direct contact with the skin or mucosa and by application of electric field pulses at specified intervals. An electrode membrane can be assembled such that it incorporates an iontophoretic electrode in the same device. This device can be jointly utilized for electroporation and iontophoretic drug delivery through the skin and mucosal membrane.

Method for in vivo delivery of therapeutic agents

Electroporation device for in vivo delivery of therapeutic agents

Apparatus and method for in vivo delivery of therapeutic agents

It is the object of the present invention to provide an iontophoresis device structure which has excellent contouring ability at its site of attachment, has very high safety, is of high quality with high product yields, and can be produced with fewer production steps to improve working efficiency and increase productivity to allow mass production at low cost. The iontophoresis device structure of the present invention has a construction provided with a cup-shaped support including a concave part, at least one electrification hole formed in the concave part, an electrode layer laid on the flat part of the rim of the concave part, and an electrolyte layer or drug-holding layer fitted into the concave part.

Growing community of inventors

Tsukuba, Japan

Kenji Mori