Kyoto University

Orizuru Therapeutics, Inc.

Nintendo Co., Ltd.

Takeda Pharmaceutical Company Limited

Ips Academia Japan, Inc.

Kenji Miki

Shinya Yamanaka

Yoshinori Yoshida

Hirohide Saito

Kei Endo

Seiya Takahashi

Shigeru Kondo

Hiroshi Nara

Akira Kaieda

Yoshinori Ikeura

Misato Koakutsu

As a technology for enriching atrial myocytes or ventricular myocytes in a cardiomyocyte-containing cell population induced from stem cells, provided is a method for enriching atrial myocytes or ventricular myocytes in a cardiomyocyte-containing cell population induced from stem cells, the method including a step of collecting atrial myocytes or ventricular myocytes from the cell population by using the expression level of CD151 as an index.

Method for enriching cardiac myocytes

The present invention provides a cardiomyocyte maturation promoter. The present invention provides a cardiomyocyte maturation promoter comprising one or more compounds selected from 2-methoxy-5-((Z)-2-(3,4,5-trimethoxyphenyl)vinyl)phenol,

Cardiomyocyte maturation promoter

The present invention provides a heterocyclic compound having an activity to promote the maturation of a cardiomyocyte. A compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof has an activity to promote the maturation of a cardiomyocyte, and is useful as a cardiomyocyte maturation promoter.

Heterocyclic compound

An object of the present invention is to provide a novel method for sorting cardiomyocytes. Another object of the present invention is to provide a method for producing high-purity cardiomyocytes and a kit used therefor. The present invention provides a method for sorting cardiomyocytes, comprising a step of introducing miRNA-responsive mRNA into a cell group, wherein the miRNA-responsive mRNA consists of a sequence comprising the following (i) and (ii):

Method for sorting cardiomyocytes

An object of the present invention is to provide a method for increasing the purity of a type of tissue cell such as an endothelial cell, a hepatocyte, or an insulin-producing cell. The present invention solves the problem by providing a method comprising a step of introducing, into a cell population, an mRNA comprising a nucleic acid sequence recognized by an miRNA specifically expressed in endothelial cells, hepatocytes, or insulin-producing cells.

Method for sorting tissue cells

The present invention provides a method for efficiently producing cardiomyocytes from pluripotent stem cells, which method comprises the steps of dissociating embryoid bodies obtained during the production process, and allowing reaggregation of the resulting cells to allow formation of embryoid bodies.

Method of efficiently inducing cardiomyocytes

A game apparatus includes a CPU, and the CPU executes game processing of a golf game, and displays a guide path of a circle a part of which is erased in a hitting operation. When the player performs a sliding operation in a clockwise direction so as to trace the guide path, and then inverts the sliding operation in a counterclockwise direction, the player character performs a swing motion according thereto. As to each of backswing, downswing and follow-through, precision, a speed, smoothness of the sliding operation are determined, and in accordance with the results, the movement of a ball is controlled.

Growing community of inventors

Kyoto, Japan

Kenji Miki