Shionogi Company Limited

Kenji Matsuo

Masami Takayama

Masaharu Kume

Naoki Omori

Takeshi Endo

Aiko Omori

A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided. A compound represented by the general formula (I): wherein Ris a group represented by the formula: wherein Ris a hydrogen atom, optionally substituted alkyl, etc.; Z is &#x2014;O&#x2014;, &#x2014;N(R)&#x2014;, etc.; Ris a hydrogen atom, alkyl, etc.; Ris a hydrogen atom, optionally substituted alkyl, etc.; Ris a hydrogen atom, optionally substituted alkyl, etc.; Ris optionally substituted alkyl, etc.; Wis an optionally substituted non-aromatic nitrogen-containing group; Ris a hydrogen atom, optionally substituted alkyl, etc.; Rand Rare independently a hydrogen atom, optionally substituted alkyl, etc.; X is &#x2014;O&#x2014;, &#x2014;S&#x2014;, or &#x2014;N(R)&#x2014;, etc.; Ris a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc.,its pharmaceutically acceptable salt, or a solvate thereof.

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Osaka, Japan

Kenji Matsuo