Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Kenji Kawamura

Hamao Umezawa

Tomio Takeuchi

Takaaki Aoyagi

Shunzo Fukatsu

Mitsugu Hachisu

Yasuharu Sekizawa

New 3-N-acyl derivatives of 3-amino-2-hydroxy-4-phenylbutanoic acid are provided, which exhibit analgesic activity and are affective to enhance the morphine analgesia.

3-Amino-2-hydroxy-4-phenylbutanoic acid derivatives and pharmaceutical

3-Amino-2-hydroxy-4-phenylbutanoic acid and esters thereof as well as new derivatives thereof which are related to bestatin in their chemical structure are active to enhance the immune response in living animals.

Bestatin-related compounds as immunopotentiator

A new analgesic agent is now provided, which comprises as the active ingredient 3-amino-2-hydroxy-4-phenylbutanoic acid and some related compounds thereof. These compounds have now found to be effective as inhibitor against enkephalinase and as an agent for enhancing analgesic activity of morphine.

Growing community of inventors

Ohiso, Japan

Kenji Kawamura