Taiho Pharmaceutical Company Limited

Otsuka Kagaku Kabushiki Kaisha

Otsuka Kagaku Yakuhin Kabushiki Kaisha

Kenji Kase

Hideo Tanaka

Michio Sasaoka

Daisuke Suzuki

Masatoshi Taniguchi

Motoaki Tanaka

Shigeru Torii

Hisashi Takao

Yoshifumi Nakacho

Akira Nakai

Yasuo Shimizu

Ichiro Kawahara

Kiyotoshi Matsumura

Tsunehiko Masatomi

Takeshi Misawa

Rokuro Harima

The present invention provides a process for preparing a penicillanic acid derivative of the formula ##STR1## which comprises reacting lead with a halogenated penicillanic acid derivative of the formula ##STR2## wherein X, Y, Z and R.sup.1 are as defined in the specification. The reaction is advantageously conducted in the presence of a metal having higher ionization tendency than lead such as aluminum, iron, magnesium or a mixture thereof.

Process for preparing penicillanic acid derivatives

2,2'-BIS(3,4-Epoxy-5-oxotetrahydropyran)ethers represented by the formula ##STR1## wherein R is hydrogen atom or straight-chain or branched-chain alkyl having 1 to 6 carbon atoms; a process for preparing the same.

2,2'-Bis(3,4-Epoxy-5-oxotetrahydropyran)ethers

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Tokushima, Japan

Kenji Kase