Eisai Company, Limited

Komori Corporation

Eisai R&d Management Co., Ltd.

Kenji Hayashi

Shinya Abe

Isao Yamatsu

Takeshi Suzuki

Hironori Ikuta

Kouji Nakamoto

Kozo Akasaka

Mitsuaki Miyamoto

Youji Yamagishi

Tohru Fujimori

Hiroyuki Yoshimura

Koukichi Harada

Kazuo Okano

Issei Ohtsuka

Shigeru Souda

Norio Minami

Nobuhisa Watanabe

Noriyasu Hirose

Chiaki Seki

Hironobu Hiyoshi

Yuh Horikawa

Toshio Matsunami

Kouzou Morita

Hiroshi Inoue

Takashi Yoshimura

Noriyoshi Iwata

Shigeto Negi

Katsuya Tagami

Akiharu Kajiwara

Hiroshi Tanaka

Yoshio Fukuda

Naoki Kobayashi

Makoto Kaino

Hiroyuki Shiojiri

Norihiro Kumagai

Yoshihito Eguchi

Naoki Ozeki

Makoto Nakagawa

Ichirou Yoshida

Issei Otsuka

Takashi Kato

Isao Saito

Naoyuki Shimomura

Seiichi Kobayashi

Tetsuya Kawahara

Keisuke Matsuyama

Osamu Asano

Kazutoshi Miyake

Hitoshi Oinuma

Manabu Murakami

Teiji Kimura

Keiko Takahashi

Hiromitsu Numauchi

Tsutomu Kawata

Naoki Yoneda

Masanobu Shinoda

Hitoshi Harada

Fumiyoshi Matsuura

Takashi Inoue

Satoshi Katayama

Makoto Kotake

Toshihiko Naito

Takao Saeki

Yasutaka Takase

Toshikazu Shimizu

Manabu Sasho

Nobuyuki Mori

Nobuyuki Yasuda

Junsaku Nagaoka

Toshiyuki Matsuoka

Mamoru Saito

Tatsuo Horizoe

Seiji Yoshikawa

Shinji Suda

Takao Omae

Isao Tanaka

Masayuki Tanaka

Toru Horie

Makoto Matsui

Kaoru Murata

Yoshinori Sakuma

Taichi Abe

Yutaka Endo

Motoji Kogushi

Hiroe Minami

Susumu Inoue

Hiroko Kobayashi

Katsutoshi Nishiura

Mamoru Miyazawa

Masayuki Namiki

Takeshi Sudo

Soichi Nakamura

Kaya Ohashi

Koichi Nose

Masaharu Gotoda

Teiji Takigawa

Toyokazu Haga

Mitsuhiro Uehara

Masahiro Ishiwata

Shigeru Yanagawa

Provided is a method for automatically adjusting the contact pressure between an intaglio cylinder and a wiping roller that further limits the amount of defective prints generated. The method adjusts said contact pressure by changing the position of the wiping roller shaft center with respect to the intaglio cylinder shaft center using a contact pressure adjustment motor. At least the position of the wiping roller shaft center at low speed and the position of the wiping roller shaft center during printing operation for which the contact pressures have been optimized during a previous printing are stored. Before starting the current printing operation, the wiping roller is moved to the stored low speed position. Then when the current printing operation is started, the wiping roller is moved to the stored printing operation position.

Method and device for adjusting contact pressure of intaglio printer wiping roller

According to a drive control method and apparatus, an offset printing section and an intaglio printing section are connected together by a gear train. Separately from an offset printing section prime motor for driving an entire sheet-fed printing press, an intaglio printing section auxiliary motor is provided in the intaglio printing section where load is heaviest and load variations are great. By so doing, the entire sheet-fed printing press is driven by the offset printing section prime motor and the intaglio printing section auxiliary motor. Moreover, the electric current value (driving torque value) of the intaglio printing section auxiliary motor is controlled in accordance with an electric current value (torque value) for driving the offset printing section prime motor, the torque distribution rate of the intaglio printing section auxiliary motor, and the rated electric current value of the intaglio printing section auxiliary motor.

Drive control method and drive control apparatus for printing press

The present invention relates to calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy) -2-fluoropropoxy]phenyl]-2-isopropoxypropionate] represented by formula (I), a hydrate thereof, a crystal of the compound of formula (I), and a crystal of the hydrate of the compound of formula (I) which are useful as pharmaceuticals, and to processes for producing the same, and intermediates therefore, and processes for production thereof. There is need for (2S)-3-[3-[(2S)-3-(4 -chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, in the form of a drug substance, purified so as to minimize a residual solvent content and having a uniformized specification and a highly favorable workability, and a process for producing the same. Crystalline calcium bis[(2S)-3-[3-[(2S)-3-(4 -chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate], a calcium salt of (2S) -3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, solves the above problem.

Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof

A crystalline form of N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzenesulfonamide having a diffraction peak at a diffraction angle (2&#x3b8;&#xb1;0.2&#xb0;) of 19.1&#xb0; in a powder X-ray diffraction.

Crystalline sulfonamide-containing indole compound and process for preparing the same

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I);(wherein Rrepresents e.g. an amino group which may be substituted with an alkyl group; Rrepresents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; Rrepresents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.

Condensed imidazole compounds and a therapeutic agent for diabetes mellitus

An inspection unit of an intaglio printing press includes a suction table for correcting the position of printed sheet-like object as being disposed inside of a unit frame, and a camera and a light for inspecting the printing quality of sheet-like object being corrected of position by the suction table provided in a shroud inside of the unit frame. The table is disposed in a moving table with casters so as to move the suction table between a working position inside of the frame and a maintenance position outside thereof. The shroud is supported on first support rails through support rollers so that the camera and light can be moved between the working position inside of the frame and the maintenance position outside thereof, while support rails and their stand are disposed so as to be accommodated outside the frame.

Printing quality inspection apparatus

A process is provided for the preparation of .alpha.-tocopherol. According to the process, a condensation reaction between trimethylhydroquinone and a specific phytol derivative or isophytol is conducted in the presence of any one of the following solvents:

Process for the preparation of .alpha.-tocopherol

Phosphonic acid derivatives

The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibition activity. This amino acid derivative is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or an acyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an ary group which may have a substituent, a heteroaryl group which may have a substituent, an arylalkyl group which may have a substituent or a heteroarylalkyl group which may have a substituent;

Amino acid derivative

A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R.sup.1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R.sup.2 stands for a group represented by the formula: ##STR2## (wherein R.sup.16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R.sup.3 stands for a group represented by the formula: --O--(CH.sub.2).sub.m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R.sup.5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: ##STR3## (wherein R.sup.6 stands for a hydrogen atom, a lower alkyl group, or the like), --N.dbd., or the like; and B stands for a group represented by the formula: ##STR4## (wherein R.sup.4 stands for a hydrogen or the like), --N.dbd., or the like.

Trisubstituted benzene derivatives, composition and methods of treatment

Benzene derivatives and method of treating arteriosclerosis with benzene

Phosphorus-containing isoprenoid derivatives

A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime either derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,

Diphenylethylene derivatives, pharmaceutical compositions containing

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Tsukuba, Japan

Kenji Hayashi