Shiseido Company, Limited

Kyushu University

Kagami Inc.

Kanazawa University

Osaka University

Kenji Hamase

Masashi Mita

Yurika Miyoshi

Yousuke Toujo

Tsubasa Oyama

Yasunori Iwata

Yusuke Nakade

Kengo Furuichi

Tomonori Kimura

Yukimitsu Suda

Chieko Mizumoto

Akinori Hara

Takashi Wada

Yutaka Ashida

Yoshitaka Isaka

Norihiro Sakai

Kiyoshi Zaitsu

Norihiko Sakai

Maiko Nakane

Keiko Yasuda

Shoto Ishigo

Tadashi Ueda

The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, a kidney inflammation inhibitor, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-alanine or a derivative thereof. In addition, the present invention pertains to the use of D-alanine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.

Pharmaceutical composition for prevention or treatment of kidney damage

The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.

Kidney disease prognosis prediction method and system

The present invention addresses the problem of developing an analytical method which makes it possible to diagnose early or mild renal disorders. The method is based on calculating a disease-state index value for renal disorders on the basis of the quantities of D-form and/or L-form amino acids, from feces or intestinal content. By comparing the disease-state index value with a threshold value determined from the disease-state index values of a renal failure patient group and a healthy subject group, it is possible to diagnose a mild renal disorder patient group.

Disease-state biomarker for renal disease

A chiral analysis method of a bound amino acid includes a step of hydrolyzing a bound amino acid using a deuterium chloride-deuterium oxide solution and/or deuterium oxide; a step of separating, by chiral separation, a D-form and an L-form of an amino acid generated by the hydrolyzation; a step of generating fragments from the separated amino acid; and a step of selecting and analyzing a predetermined fragment that contains an &#x3b1; carbon and does not contain a side chain from the generated fragments, by mass spectrometry.

Chiral analysis method of bound amino acid and chiral analysis system

The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

Marker for early diagnosis of kidney failure

Disclosed is a compound represented by chemical formula (1): or chemical formula (2): 

Compound, optical resolution method, and derivative of an optical isomer of an amino acid

An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.

Separating agent and manufacturing method thereof

A method for quantitatively analyzing cysteine and cysteine includes a first step of adding a methyl-sulfurating agent to a sample that includes cysteine and cystine to obtain a methyl-sulfurated cysteine, a second step of adding a derivatizing agent to the methyl-sulfurated cysteine and the cystine to obtain a cysteine derivative and a cystine derivative, respectively, and a third step of quantifying the cysteine derivative and the cystine derivative.

Method for quantitatively analyzing cysteine and cystine and reagent kit for quantitatively analyzing cysteine and cystine

Disclosed is an evaluation method which can rapidly discriminate a Daohomozygote from a large number of animals produced in a mating experiment between a DAO enzyme deficient mouse and other disease model mice, to rapidly perform a quantitative measurement of the D-amino acids contained in a large number of samples. The invention provides a method for evaluating the effect of a test condition on a mouse tissue, or cultured tissue cells derived from the tissue. The method comprises the steps of: providing a Dao1mouse or the like; exposing the tissue from the Dao1mouse or the like, to the test condition; and analyzing the effect of exposing the tissue from the Dao1mouse or the like, to the test condition.

Evaluation/screening method for diseases associated with D-amino acid utilizing DAO1-/-mouse

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Fukuoka, Japan

Kenji Hamase