Fujifilm Corporation

Kenichiro Tamaki

Yoshiki Sakazaki

Toshihiro Usa

Satoshi Wakamatsu

Shotaro Ogawa

Ikuo Takano

Keio Okano

Yuka Kobayashi

The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying. Provided are a microneedle arrayincluding a sheet portion, a plurality of needle-like protrusions, and a support memberformed of a gripping portionand a beam portionhaving one end that is connected to the gripping portion, in which the sheet portionis an integrally molded body which is integrally molded with the support member, in which at least a part of the beam portionis buried under the other surfaceof the sheet portion, opposite to the one surface where the needle-like protrusionsare provided, the gripping portionis provided on the other surfaceof the sheet portion, and the beam portionis deformable toward a center of the sheet portion. Further, provided are the support member, a method of producing the microneedle array, and a microneedle array unitincluding a container

Microneedle array, support member, method of producing microneedle array, and microneedle array unit

Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

Method of manufacturing microneedle array

Provided are a microneedle array capable of improving the visibility of an appearance inspection, and a manufacturing method of the same. A microneedle array is a microneedle array including: a sheet portion having a first surface and a second surface which oppose each other; and a plurality of needle portions arranged on the first surface of the sheet portion, in which the second surface of the sheet portion is configured by a rough surface having peak portions and valley portions, and an average transmittance of the sheet portion in a wavelength range of 300 nm to 740 nm is 75% or less.

Microneedle array and manufacturing method of same

Provided are a mold case that prevents deformation of a microneedle array, and a manufacturing method of a microneedle array. The problems are solved by the manufacturing method of a microneedle array including: a filling step of filling needle-like recessed portions of a mold having flexibility and having a plurality of the needle-like recessed portions on a front surface, with a liquid material; and a drying step of drying the liquid material in a state where the mold filled with the liquid material is stored in the mold case which causes an edge portion of the mold to be sandwiched between the lid and the pedestal.

Mold case and manufacturing method of microneedle array

Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer () on needle-like recess portions () of a mold () having the needle-like recess portions (), a step of supplying a polymer layer forming solution () to the inside of a step portion () of the mold (), a step of drying the polymer layer forming solution () so as to form a polymer layer () and a transdermal absorption sheet (), and a step of peeling off the transdermal absorption sheet () from the mold (). In the step of peeling off, pressing force is applied to a part of the step portion () in a second direction (B) opposite to a first direction (A) in which the transdermal absorption sheet () is released from the mold (), and the transdermal absorption sheet () is aspirated with a vacuum suction pad () from a side opposite to the mold () so that the transdermal absorption sheet () is peeled off from the mold () in the first direction (A).

Method for manufacturing transdermal absorption sheet

Provided are a production method of a mold having a recessed pattern, and a manufacturing method of a pattern sheet having good accuracy and excellent productivity. The production method of a mold includes: a step of preparing an electroform having a protruding pattern and a mold having a first mold and a second mold forming a cavity; a step of fixing the electroform excluding an end portion of the electroform to the first mold; a clamping step of clamping the electroform excluding the end portion of the electroform and a region of the protruding pattern between the first mold and the second mold to form the cavity; and an injection step of filling the cavity with a resin.

Production method of mold having recessed pattern, and manufacturing method of pattern sheet

Provided is a method for manufacturing a transdermal absorption sheet which suppresses the cost of manufacturing equipment and prevents deterioration of a pharmaceutical preparation or a raw material thereof, and an intermediate. A mold filled with a first polymer solution is stored in a drying container in an aseptic environment, and the first polymer solution in the mold stored in the drying container is dried outside an aseptic environment. In a case where a surface of the drying container in which the mold is stored is irradiated with an electron beam from an electron beam source, a shield that shields an electron beam is arranged at a position on a straight line connecting the electron beam source and the needle-like recessed portions.

Provided is a method of producing a transdermal absorption sheet using an electroforming mold. A method of manufacturing an electroforming mold includes preparing a mold which is a matrix having a recessed pattern, immersing the mold in a degassed pretreatment liquid stored in a pretreatment liquid tank, then applying ultrasound waves generated from an ultrasound oscillator to the recessed pattern of the mold, and filling recessed portions constituting the recessed pattern with the pretreatment liquid. By immersing the mold in an electroforming tank and performing an electroforming treatment, an electroforming mold is manufactured. A mold having a recessed pattern is manufactured from the electroforming mold and a transdermal absorption sheet is produced using the mold.

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Kanagawa, Japan

Kenichiro Tamaki