Teijin Pharma Limited

Teijin Limited

Kenichiro Takagi

Hiroshi H Eguchi

Akira Tanokura

Naoko Namiki

Kazuyoshi Yamaoka

Satoshi Yamamura

Hirotsugu Kato

Hiroshi Saito

Masanori Yamamoto

Jun Shibata

Hidekazu Watanabe

Kenichiro Kataoka

Kenichi Masuda

Gen Unoki

Hirofumi Higuchi

Kosuke Sasaki

Eiji Ochiai

Kyohei Horie

Masato Komiyama

Keiichiro Imaizumi

Toshihiro Chikanishi

Hiroko Ogawa

Yoshinori Sugimoto

Susumu Yasuoka

Tetsuya Suga

Shinnosuke Hosoda

Emi Yokoyama

Takayuki Chida

Mariko Fujita

Toshiyuki Kaneko

Daisuke Ishikawa

Masayo Ohori

Tomoyo Takeo

Provided is a humanized antibody that, through IGF-I receptor, increases muscle mass but does not lower the blood glucose level. This humanized antibody: is an anti-IGF-I receptor humanized antibody, a fragment thereof, or a derivative thereof; has a specific amino acid sequence such as SEQ ID NOs: 1 to 6 serving as a CDR sequence; and specifically binds to IGF-I receptor extracellular domain.

Anti-IGF-I receptor humanized antibody

The present invention provides an anti-IGF-I receptor antibody that binds specifically to an IGF-I receptor of a vertebrate and has the proliferation-inducing activity of a vertebrate-derived cell, or a fragment thereof, or derivatives of these.

Anti-IGF-I receptor antibodies, encoding nucleic acid molecules and methods of using said antibodies

A compound, represented by the following formula or a medically acceptable salt thereof, having an effect of regulating the activity of an androgen receptor. In the formula, X represents S, O; Z represents (R)-A-(CRR)&#x2014;(CRR); A represents aryl, heteroaryl; Rrepresents alkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl; Rrepresents hydrogen, halogen, alkyl, cycloalkyl, phenyl; R3 represents hydrogen, halogen, alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, RRNCO&#x2014;; Rand Rrepresent hydrogen, halogen, alkyl, phenyl, and cycloalkyl. 

Aminoazole derivative

To provide a novel vitamin Dderivative useful as a therapeutic agent for osteoporosis. Provided is a vitamin Dderivative represented by the following formula (1) or a medicinally acceptable solvate thereof: 

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The present invention provides a method for screening a substance having a thermogenesis enhancing effect containing a compound having an effect activating PPAR &#x3b4;, an agent containing the compound, and an agent having antidiabetic, antiobestic or visceral accumulated fat-lowering function. The present invention provides an agent containing a compound having an effect activating PPAR &#x3b4;, which is a peroxisome proliferator activated receptor, and having effects which enhances nonshivering thermogenesis (nST), specifically enhances uncoupling respiration in mitochondria of cells in an adipose tissue or the like, or proton leak in inner membranes of mitochondria, and increases the amount of expression of UCP1, and provides an antidiabetic agent, an antiobestic gent and a visceral accumulated fat-lowering agent containing the compound. Further, the present invention provides a method for screening the compound by measuring a PPAR &#x3b4; activating effect.

Methods of screening for a compound that enhances thermogenesis

This invention provides a nucleic acid sequence encoding a trypsin-like enzyme which can be present at the trachea of human lungs, and can selectively digest a synthetic substrate for trypsin and a synthetic substrate for thrombin, and fibrinogen; and a process for producing the trypsin-like enzyme by genetic engineering utilizing the nucleic acid sequence.

Nucleic acid sequence encoding trypsin-like enzyme and process for

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Tokyo, Japan

Kenichiro Takagi