Konishiroku Photo Industry Co., Ltd.

Konica Corporation

Chugai Seiyaku Kabushiki Kaisha

Kenichiro Okaniwa

Mikio Koyama

Shozo Kikugawa

Takashi Sasaki

Morio Kobayashi

Kazumi Arai

Toyoaki Masukawa

Wataru Ishikawa

Kiyoshi Yamashita

Masakuni Saruhashi

Kunihiro Furukawa

Eiichi Sakamoto

Yasuo Tosaka

Satoshi Kawakatsu

Hiroshi Sugita

Keiji Ogi

Takashi Uchida

Kiyoshi Tamaki

Shizuo Saito

Masao Iwamuro

Takeshi Murakami

Mario Kobayashi

Tomoji Akashi

Shozo Kikukawa

Takasi Momose

Yuko Ohmachi

Masaharu Nonaka

Seikichi Yasoshima

Soichi Zanma

Souichi Zanma

A method of manufacturing a color filter having a substrate comprising black matrix sections and image forming sections, comprises a step of applying a treatment onto the substrate so as to provide influence to a contact angle between an ink meniscus and the black matrix sections before applying an ink onto the substrate.

Color filter manufacturing method, color filter and liquid crystal displayer

Disclosed is a multilayered assay element in which the influence by the bilirubin contained in the sample fluid is substantially eliminated. The assay element of the present invention contains a bilirubin-trapping agent of the formula

Multilayered assay element

A stable dry multi-layer analytical element for enzyme or triglyceride analysis in a fluid sample is prepared containing first and second layers on a support. The first layer contains a tetrazolium salt as a dye forming precursor. The second layer is adjacent the first layer and contains an electron-transmitting agent. Either layer contains a co-enzyme in oxidized form and either layer contains a reagent containing an enzyme substrate, enzyme or co-enzyme other than the oxidized co-enzyme. The analytical element has improved storage stability and low fog density before and after storage.

Dry multilayer analytical element for analysis of enzymes or

An analytical element to measure a specific component in a fluid samples comprising support, a layer containing a reagent provided the support and a spreading layer provided on above the reagent containing layer. In the spreading layer, an emzyme necessary for the reaction to produce a product capable of being detected with said reagent from the specific component is contained. The enzyme is protected from deterioration of activity during a manufacturing and preservation of the analytical element by means of the enzyme is included in the spread layer as a dispersion mixture with a protein and/or polypeptide. An accurate analytical result is stably obtained by the analytical element.

Multi-layer analytical element with preserved enzyme containing

An analytical element for the detection of hydrogen peroxide comprising a peroxidase-functional material, a hydrogen donor and a coupler, wherein the peroxidase-functional material and hydrogen donor are arranged so as to be separate from each other, for example in separate layers, but are made interactive by the application of a fluid sample.

Analytical element for the detection hydrogen peroxide

There is disclosed an immunoassay comprising carrying out an immunological reaction by contacting a fluid sample with an element for immunoassay, having at least three layers of a first detecting layer, a blocking layer and a second detecting layer which are successively laminated, the element containing a substance capable of binding specifically to an immunologically active substance in a fluid sample only in either one of the first and the second detecting layers, and then measuring the detected quantities corresponding to the immunological reaction quantities from both of the first and the second detecting layers. The immunoassay by the use of the immunological analytical element according to this invention improves the precision immunoassay by measuring both of Bound and Free.

Immunoassay method for measuring immunological antigen in fluid sample

There is presented an improved simple quantitative analytical element for analysis of components in a body fluid such as blood, having a reagent layer constituted of a hydrophilic colloid containing at least one reagent reactive with a component in a liquid sample provided on a support, and also a development layer of a fibrous structure on the reagent layer on the opposite side to the support. A liquid sample can be distributed uniformly through the reagent layer to enable quantitative analysis.

Analytical element

An improved multilayer analytical element for the determination of calcium comprising a liquid impermeable, optically transparent support; at least one reagent layer positioned with a first side on said support and containing at least one reagent capable of reacting with a calcium component in a fluid sample; and at least one porous developing layer on the second side of said reagent layer, said porous developing layer being permeable to calcium from said fluid sample thereby transporting said calcium to said reagent layer. The improvement comprises at least one of said reagent layer and developing layer containing a basic substance of the formula M.sub.v H.sub.w PO.sub.4 .multidot.ZH.sub.2 O wherein M is lithium, sodium or potassium; v is an integer of 2 or 3 and w is an integer of 0 or 1 provided that v plus w equals 3; and Z is 1/2 when M is lithium, 0, 2 or 12 when M is sodium and 0 or 8 when M is potassium; and said reagent layer contains (i) 3,3'-bis[N,N-di(carboxymethyl)aminomethyl]-o-cresolphthalein and (ii) 8-hydroxyquinoline or a derivative thereof.

Elements for analysis of calcium

There is disclosed an analytical element comprising a support; a reagent layer which is positioned on one side of the support and contains a reagent reactive with a component in a fluid sample; and a porous spreading layer which is positioned on the reagent layer on the opposite side to that of the support for permitting the component in the fluid sample to permeate into the reagent layer; wherein at least one layer contains 5% by weight or more of a polymer formed by, (i) a copolymerizable ethylenically unsaturated acid with (ii) a copolymerizable ethylenically unsaturated monomer. The analytical element according to the present invention can determine a component in a fluid sample quantitatively.

An analytical element comprising a light-transmissive and liquid-impervious support having thereon, in order from the support side, at least one reagent layer containing at least one kind of reagent reactive with a component in a fluid sample, a shielding layer and at least one porous spreading layer, said shielding layer comprising at least a white pigment and a substantially water-dispersible reactive polymer which comprises a copolymer having (i) monomeric units which have a reactive group and (ii) at least one kind of other hydrophobic monomer.

There is disclosed an analytical element which comprises a support and a reagent layer comprising a peroxidative substance, a diffusion-resistant phenol compound, and an aromatic primary amine compound or its salt which brings about a coupling reaction with said diffusion-resistant phenol compound when oxidized, to thereby produce a dyestuff.

An analytical element for use in analysis of a component in an aqueous fluid, comprising

There is disclosed an analytical element comprising a light-transmissive and liquid-impermeable support and at least one developing layer of a fibrous structure containing at least one kind of interactive composition reactive with a component in a liquid sample, characterized in that the fiber constituting the developing layer of a fibrous structure and the interactive composition are bonded to each other by a compound having a reactive group. A quantitative analysis of a specific component in a liquid sample can effectively be carried out by using the analytical element according to this invention.

An analytical element comprising a light-transmissive and liquid-impervious support, at least one reagent layer containing at least one reagent which reacts with a component in a fluid sample and at least one development layer provided at a position on the reagent layer on the opposite side to that of the support for permitting the component in said fluid sample to permeate into the reagent layer, at least one layer of reagent layers being constituted of polymeric particulate units each having a core-shell multi-layer structure comprising a core, which is hydrophobic and substantially unswellable with a fluid sample, and a hydrophilic outer shell.

Analytical element and method of use

An analytical element for analysis of a liquid having an interconnected void structure zone positioned on one side of a liquid-impermeable, light-transmissive support, being characterized in that said interconnected void structure zone comprises a bound particulate structure which is a three-dimensional lattice, being non-swellable in the liquid and having interconnected voids with a void volume of 25 to 85% among the particles to provide transport of said liquid, the material for said bound particulate structure being non-swellable in and impermeable to said liquid and said bound particulate structure being constituted of heat-stable, organic polymer particle units having reactive groups with particle sizes of 1 to 350 microns which are chemically bonded directly to each other through said reactive groups in the areas of contact. A method of analysis utilizing the analytical element in immunoassay is also disclosed.

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Hino, Japan

Kenichiro Okaniwa