Mitsubishi Chemical Industries Limited

Tottori University

Nobelpharma Co., Ltd.

Kenichiro Nakao

Ryoji Kikumoto

Harukazu Fukami

Issei Nitta

Mamoru Sugano

Akira Maruyama

Kunihiko Ofuchi

Shinya Inoue

Koichiro Oda

Motoyoshi Miyake

Tasuku Harada

Fuminori Taniguchi

Hiroaki Ueno

Junko Takashima

[Problem] To provide a therapeutic agent for estrogen-dependent gynecological diseases such as endometriosis, uterine fibroids, and uterus adenomyosis. [Solution] To use an estrogen receptor &#x3b1;-inhibiting &#x3b2; partial agonist represented by the formula (a), a pharmaceutically-acceptable salt thereof, or a hydrate of either of the afore-mentioned, as an active ingredient.

Estrogen receptor &#x3b2; partial agonist having estrogen receptor &#x3b1; inhibitory effect, and gynecological disease therapeutic agent using same

A phenylpiperazine derivative according to the present invention has the following general formula [I]: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or alkoxy group having 1 to 3 carbon atoms, or

Phenylpiperazine derivatives and their acid addition salts

Alkylenedioxybenzene derivatives are prepared and found to be useful as pharmaceutical agents, particularly as hypotensives.

Alkylenedioxybenzene and acid addition salts thereof useful as

Alkylenedioxybenzene derivatives and acid addition salts thereof

A piperazine derivative according to the present invention has the following general formula [I]: ##STR1## wherein R.sup.1 is --OH, --OR.sup.3, --SR.sup.3, --SOR.sup.3 or --SO.sub.2 R.sup.3 wherein R.sup.3 is alkyl group having 1 to 3 carbon atoms;

Piperazine derivatives and their acid addition salts

Novel corticoid 17.alpha.-alkoxycarbonyl carboxylate derivatives are disclosed. These derivatives have strong topical anti-inflammatory activity and extremely weak systemic adverse reactions and are useful for the treatment of acute and chronic eczema, eczema seborrhoicorum, contact dermatitis, atopic dermatitis, asthma, etc.

Corticoid derivatives and process for production thereof

Novel 6-oxygenated corticoid 17.alpha.-carbonates are disclosed. These compounds have strong topical anti-inflammatory activity which are accompanied by extremely weak systemic adverse reaction. The present compounds are useful for the treatment of acute and chronic eczema, eczema seborrhoicorum, contact dermatitis, atopic dermatitis, asthma, etc.

6-oxygenated corticoid 17.alpha.-carbonates and process for production

Skin preparations containing a phosphatide, a topical corticosteroid, and butylhydroxyanisole and/or butylhydroxytoluene, which may be in the form of an aqueous or oily mixture, non-aqueous, water-soluble base or suspension base. These preparations can be applied to various skin diseases including eczema, lichen, ichthyosis and psoriasis, possess improved therapeutic activities and are stable for a prolonged period of time.

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Tokyo, Japan

Kenichiro Nakao