Tohoku University

Kake Educational Institution

Kake Education Institution

Kanagawa Prefectural Hospital Organization Kanagawa Children's Medical Center

Kanagawa Prefectural Hospital Organisation Kanagawa Children's Medical Center

Kenichiro Hayashi

Takaaki Abe

Teiji Tominaga

Hitoshi Osaka

Nobuo Yaegashi

Yukio Katori

Michiaki Unno

Masahito Tachibana

Yohei Honkura

Fumika Nanto

Shinobu Ohnuma

An object of the present invention is to provide a low molecular weight compound having a prophylactic or therapeutic action on cancer. A compound of the following formula (1), a compound of the following formula (2), or the like can be administered by a method such as oral administration to prevent or treat cancers such as colorectal cancer.

Prophylactic or therapeutic agent for cancer

An object of the present invention is to provide an agent for enhancing fertilization function of a mammal sperm, which comprises a low molecular compound which can be produced relatively easily and inexpensively as an active ingredient, and a method for enhancing fertilization function of a mammal sperm and a method for preparing a mammal fertilized egg, which use a low molecular compound which can be produced relatively easily and inexpensively. An agent comprising one or more compounds selected from the group consisting of compounds of the following formula (I), formula (II), and formula (III), and physiologically acceptable salts thereof when Ris OH is used as an agent for enhancing fertilization function of a mammal sperm.

Enhancer of fertilization function of sperm

It is to provide an agent for preventing or improving hearing loss, which comprises a low molecular compound which can be produced relatively easily and inexpensively as an active ingredient. One or more compounds selected from the group consisting of compounds represented by the following formulas (I), (II), and (III) and a pharmaceutically acceptable salt of the compounds when Ris OH are used as an agent for preventing or improving hearing loss. 

Agent for preventing or ameliorating hearing impairment

The present invention provides an erythropoietin expression-enhancing agent that can cancel the suppression of erythropoietin production or promote erythropoietin production, and a therapeutic or preventive drug for anemia, a liver function-improving agent, an ischemic injury-improving agent, a renal protective agent, and an insulin secretagogue comprising the erythropoietin expression-enhancing agent. The erythropoietin expression-enhancing agent of the present invention comprises one or more compounds selected from the group consisting of compounds represented by the following general formulas (I), (II), and (III) and pharmaceutically acceptable salts thereof when Ris OH. 

Erythropoietin expression promoter

Growing community of inventors

Okayama, Japan

Kenichiro Hayashi