Yamanouchi Pharmaceutical Company Ltd.

Other

Kenichi Tomioka

Kiyoshi Murase

Toshiyasu Mase

Hiromu Hara

Masuo Murakami

Isao Yanagisawa

Toshinari Tamura

Hidenori Iwamoto

Yoshio Ishii

Noriyoshi Inukai

Ryuji Tsuzuki

Hideki Arima

Tetsuya Shiozaki, Deceased

Takeshi Suzuki

Kunihiro Niigata

Hitoshi Nagaoka

Yoso Numasaki

Takumi Takahashi

Hiroitsu Kawada

Toshimitsu Yamada

Osamu Hasegawa

Hidefumi Matsui

Hideya Matsuda

Hiroo Maeno

Tetsuya Shizaoki

Tokuichi Takagi

Tetsuya Shiozaki

Toshiyasyu Mase

Shinichiro Kobayashi

Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis (SRS-A).

Thiazole compounds as inhibitors of SRS-A

This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH.sub.2 --S--directly bound to the specific heterocyclic group. These heterocyclic compounds are useful as medicines, particularly as antagonists of SRS-A (slow reacting substance of anaphylaxis).

Heterocyclic compounds

Heterocyclic compounds and pharmaceutical use thereof

Novel phenylene derivatives shown by the general formula ##STR1## where A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, B represents ##STR2## wherein R.sub.2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A(slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.

Phenylene derivatives, compositions and use

Novel phenylene derivatives shown by the general formula ##STR1## wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, B represents ##STR2## (wherein R.sub.2 represents a hydrogen atom, a halogen, atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.

Phenylene derivatives

Phenylene derivatives and anti-allergic use thereof

A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. ##STR1##

Saturated heterocyclic carboxamide derivatives

This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH.sub.2 --S-- directly bound to the specific heterocyclic group. These heterocyclic compounds are useful as medicines, particularly as antagonists of SRS-A (slow reacting substance of anaphylaxis).

Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis(SRS-A).

Pyrimidine compounds as antagonists of SRS-A

Thiadiazole compounds as antagonists of SRS-A

Thiadizazole compounds as antagonists of SRS-A

A catechol derivative represented by the formula ##STR1## The compounds of this invention are useful for the prophylaxis and treatment for various allergic diseases, ischemic heart diseases and inflammations caused by slow reacting substance of anaphylaxis (SRS-A), since the compounds inhibit very potently the formation and release of SRS-A.

Catechol derivatives and pharmaceutical compositions thereof for

A novel 2-phenylimidazo[2,1-b]benzothiazole derivative shown by the following formula ##STR1## or a salt thereof which possesses an immunoregulatory action and is useful as an antiallergic agent, an antiasthmatic, and a suppressant of rejection at tissue transplantation and skin graft.

2-Phenylimidazo [2,1-b]benzothiazole derivatives

Novel 2-phenylimidazo[2,1-b]benzothiazole compounds shown by general formula I ##STR1## and the salts thereof, a process of producing the compounds, and pharmaceutical compositions containing the compounds. The compounds of this invention act on immune response, in particular, suppress a delayed type hypersensitivity reaction, and are useful as antiallergic agents, antirheumatics, therapeutic agents for autoimmune diseases, and suppressants of rejection at tissue transplantation and skin graft.

2-Phenylimidazo[2,1-b]benzothiazole compounds, salts thereof, process of

A novel 2-hydroxyoxanilic acid derivative shown by the following formula ##STR1## or a salt thereof. This compound possesses an immunoregulatory action and is useful as an antiallergic agent, an antiasthmatic, an antirheumatic, a carcinostatic agent, a therapeutic agent for autoimmune disease, and a suppressant of rejection at the tissue transplantation and skin graft.

2-Hydroxyoxanilic acid derivatives

Growing community of inventors

Saitama, Japan

Kenichi Tomioka