Toshiba Kikai Kabushiki Kaisha

Shimadzu Corporation

Kowa Company Limited

Kenichi Suzuki

Takashi Kawabe

Eiichi Ozeki

Toshio Inagi

Makoto Kanebako

Yukio Mizota

Katsuyoshi Aiso

Eri Matsutani

Tadashi Sasaki

Takeshi Goto

Haruki Nakagawa

Yoshihiro Yamakita

Provided is a skin external preparation including a drug and nanometer-size molecular assemblies. The molecular assemblies contain an amphiphilic block copolymer having a hydrophilic block chain including a sarcosine-derived structural unit and a hydrophobic block chain including a hydroxy acid-derived structural unit. The skin external preparation according to the present invention may reduce skin irritation caused by the drug, be very safe, and have excellent pharmacological effects, even when a drug that is generally difficult to be transdermally administered due to its strong skin irritation is contained therein.

Skin external preparation and skin irritation-reducing method

Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis. An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.

Iontophoresis preparation for treating breast cancer and/or mastitis

A method of quality control of a die casting product, which method is capable of judging the quality in real time at a higher accuracy and updating and managing good quality product data for judging the higher quality thereof, includes a step of reading in measured data obtained as a result of a predetermined measurement with respect to the product cast by the die assembly in use together with the casting condition data, a step of sequentially accumulating the read measured data and casting condition data up to a predetermined capacity and performing a comparison display of the measured data combined with good quality product data to be used for judging a quality of the product, a step of repeating, if the comparatively displayed measured data are higher in quality than the present good quality product data, the above steps, then setting the accumulated measured data as a new good quality product data and updating the present good quality product data and the present casting condition data together with the above casting condition data, and a step of storing and holding the updated good quality product data and the updated casting condition data.

Method of quality control of die casting product and die casting machine

A thermal displacement correcting apparatus suitable for a machine tool (1) provided with a mechanism for feeding a main spindle (2) is disclosed. Three magnetic flux generating bodies 61 to 63 are fixed to the main spindle; a magnetic sensor (7) is fixed to the machine tool to detect the magnetic flux generated by the magnetic flux generating body at each predetermined spindle feed position; a thermal displacement value detecting section (14A) detects the thermal displacement values of the main spindle on the basis of outputs of the magnetic sensor at the respective spindle feed positions; a thermal displacement correction value calculating section (15) calculates a correction function on the basis of the detected thermal displacement values and previously determined reference values, and obtains the thermal displacement correction value in accordance with the calculated correction function at each spindle feed position; and a spindle feed command correcting section (16) corrects the spindle feed command applied to the spindle feed motor on the basis of the obtained thermal displacement correction value at each spindle feed position.

Thermal displacement correcting apparatus for machine tool

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Fuji, Japan

Kenichi Suzuki