Zenyaku Kogyo Kabushiki Kaisha

Ssd Company Limited

Kabushiki Kaisha Nichibei

Kenichi Saitoh

Toshiyuki Matsuno

Seiichiro Kawashima

Yoshimasa Yamaguchi

Tetsuo Watanabe

Naoki Fukuda

Shinichi Yaguchi

Masaya Higashi

Toshiaki Suzuki

Yoshio Tsuchida

Hideki Satoh

Soichi Ohta

Masayuki Takahashi

Hiromu Ueshima

Takeshi Nagata

Masaaki Yamagishi

Hiroomi Yamanaka

Hiroya Sasahara

Sumio Terada

Akira Sone

Yuriko Watanabe

Ryogo Yui

Mamoru Kataoka

Manami Masuda

Hitoshi Miyashita

Tomoyoshi Kayou

Shimichiro Yoshida

Mitsuo Sakato

Masato Kawashima, Legal Representative

Hiroto Kawashima, Legal Representative

Mitsuko Kawashima, Legal Representative

Ichiro Koshimizu

Naoto Tadano

Yoshie Minowa

Seiichiro (deceased) Kawashima

Disclosed are: a novel purine derivative, a composition thereof, a method for treating tumor using the purine derivative, and an antitumor agent using the purine derivative. Specifically disclosed is a compound represented by formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, or a prodrug thereof.

Purine derivative and antitumor agent using same

Disclosed is an antidepressant, neuroprotectant, amyloid &#x3b2; deposition inhibitor, or age retardant composition containing a heterocyclic compound having the general formula (I): 

Methods for treating depression, neurodegeneration, inhibiting amyloid &#x3b2; deposition, delaying senescence, and extending life spans with heterocyclic compounds

[Problem] To provide a prophylactic/therapeutic agent against, for example, nerve diseases and the like such as ischemic brain disease and neurodegenerative disease, or a prophylactic/therapeutic agent against diseases against which antioxidant action is effective, as a cell protecting agent, in particular as an inhibitor of brain cell damage or brain cell death. [Means of Solving the Problem] A compound represented by Formula (1), or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof: 

Pyrimidine derivative having cell protecting effect and uses thereof

Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Y represents C-Calkyl; Rrepresents morpholino (which may be substituted with one to four C-Calkyl); and Rand Reach represent hydrogen atom or C-Calkyl.

Heterocyclic compound and anti-malignant-tumor agent containing the same as active ingredient

An O-aryl N-(6-alkoxy-2-pyridyl)-N-alkylthiocarbamate represented by the following formula (I): (wherein R, Rand Ar are as defined below) is produced by treating a phenol represented by the following general formula (IV):Ar&#x2014;OH&#x2003;&#x2003;(IV)(wherein Ar represents an aryl group) with a base in a solvent and then adding thereto an alkali metal salt of N-(6-alkoxy-2-pyridyl)-N-alkyldithiocarbamic acid represented by the following general formula (III): (wherein Rand Rindependently represent a C-Calkyl group and M represents an alkali metal) and a halomethane represented by the following general formula (V):CHXY&#x2003;&#x2003;(V)(wherein X and Y represent different halogen atoms, m represents 0, 1 or 2, n represents 0, 1 or 2, and m+n equals 2) for causing a reaction.

Method for producing thiocarbamate derivative

Heterocyclic compound represented by the formula I wherein represents or the like; Rrepresents hydrogen atom, C-Calkyl or benzyloxy; Rrepresents methyl or nil; Rrepresents hydrogen atom, C-Calkyl, C-Calkenyl, C-Ccycloalkyl or &#x2014;CHR[wherein Rrepresents phenyl (which may be substituted with C-Calkyl, halogen atom or cyano)] or thienyl; Rrepresents C-Calkyl, C-Calkenyl, C-Ccycloalkyl or &#x2014;CHR[wherein Rrepresents phenyl (which may be substituted with C-Calkyl, halogen atom or cyano), naphtyl or thienyl]; or Ris coupled with R.

Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient

A coin image simulating a coin is displayed on a television monitor synchronized with the insertion of the coin from a coin insertion portion. The coin image moves on the television monitor. When a predetermined requirement is fulfilled, the coin is paid out from a coin ejection opening. An operating object image displayed on the television monitor can be controlled with a handle that is rotatable in clockwise and counterclockwise directions.

Game apparatus using body image appeared synchronized with inserted body

The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; Rrepresents halogen atom or hydroxyl; Rrepresents hydrogen atom, hydroxyl or amino; Rrepresents morpholino (which may be substituted with one or two C&#x2013;Calkyl), pyrrolidinyl (which may be substituted with hydroxy C&#x2013;Calkyl) or NRR[Rrepresents C&#x2013;Calkyl and Rrepresents piperidinyl (which may be substituted with C&#x2013;Calkyl)]; Rand Reach represents hydrogen atom or C&#x2013;Calkyl, with the proviso that Ris hydrogen atom and Ris pyrrolidinyl (which may be substituted with hydroxy C&#x2013;Calkyl) when Ris hydroxyl

Heterocyclic compounds and antitumor drugs containing the same as the active ingredient

Heterocyclic compound represented by the formula I wherein represents  or the like; Rrepresents hydrogen atom, C&#x2013;Calkyl or benzyloxy; Rrepresents methyl or nil; Rrepresents hydrogen atom, C&#x2013;Calkyl, C&#x2013;Calkenyl, C&#x2013;Ccycloalkyl or &#x2014;CHR[wherein Rrepresents phenyl (which may be substituted with C&#x2013;Calkyl, halogen atom or cyano)] or thienyl; Rrepresents C&#x2013;Calkyl, C&#x2013;Calkenyl, C&#x2013;Ccycloalkyl or &#x2014;CHR[wherein Rrepresents phenyl (which may be substituted with C&#x2013;Calkyl, halogen atom or cyano), naphtyl or thienyl]; or Ris coupled with R.

Azaindolizinone derivatives and cerebral function improvers containing the same as the active ingredient

A blind includes a plurality of horizontal angle-shaped slats supported by ladder-shaped supporting cords, which extend vertically from a bottom of a head box of the blind, and lifting cords, which extend from the head box through cord passing slots in the slats to a bottom rail of the blind, for raising and lowering the slats. Each of the slats has a first, porous and semi-light-transmitting part extending from an apex portion of the slat to one side edge of the slat and a second, non-porous and non-light-transmitting part extending from the apex portion of the slat to the another side edge of the slat. The cord passing slots are formed either in first parts of the plurality of slats or in the second parts of the plurality of slats, and extend from apex portions of respective slats to one edges of the slats or to another edges of the slats, respectively.

Blind with two-part angular slats having cord passing slots formed only

Growing community of inventors

Tokyo, Japan

Kenichi Saitoh