Nisshin Flour Milling Co., Ltd.

Kenichi Momose

Toshihiro Takahashi

Koichi Nakamaru

Hitoshi Inoue

Masanori Sugita

Masato Horigome

Masao Nagase

Chikako Suzuki

Shinji Nagai

Kouichi Katsuyama

Yukio Saito

Koichi Katsuyama

Masato Ariga

Shigeo Hatanaka

The pharmaceutical use of 1-cinnamoyl-2-pyrrolidinone derivatives having the activities to inhibit the production of IL-1.beta. and the release of TNF.alpha.. Those derivatives are useful in the treatment or prophylaxis of the diseases such as chronic rheumatism and sepsis.

Agents for inhibiting the production of IL-1.beta. and the release of

Disclosed are indole derivatives of formula (I) ##STR1## wherein X and Y each independently represent H or --CH.sub.2 CH.sub.2 R; R represents pyridyl or substituted amino of NR.sub.1 R.sub.2 ;

Indole derivatives

Disclosed are indole derivatives of formula (I) ##STR1## wherein X and Y each independently represent H or --CH.sub.2 CH.sub.2 R;

Disclosed are indole derivatives of formula (I) ##STR1## wherein Y represents H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy or halogen;

Indole derivatives and anti-ulcer compositions thereof

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Saitama, Japan

Kenichi Momose