Kyowa Hakko Kogyo Co., Ltd.

Abbott Laboratories Corporation

Merck + Co., Inc.

Sagami Chemical Research Center

Kenichi Mochida

Yasuki Mori

Tadashi Hirata

Junichi Shimada

Moriyuki Sato

Shigeo Yoshiie

Kiyoshi Sato

Tamotsu Eguchi

Yutaka Kanda

Tsutomu Akama

Yutaka Saitoh

Ryo Okachi

Takehiro Ogasa

Isami Takahashi

Shun-ichi Ikeda

Hiroyuki Nagata

Atsuhiro Hasegawa

Harumi Ue

Akira Sato

Mitsuru Takahashi

Koji Yamada

Makoto Morimoto

Fumio Suzuki

Chikara Murakata

Shiro Akinaga

Hiroshi Kase

Eiji Kobayashi

Kiyosi Kondo

Hiromi Nonaka

Takayuki Uwajima

Osamu Terada

Hideaki Kusaka

Tohru Yasuzawa

Yukihiro Kuge

Kohei Oshima

Hideyo Kumazawa

Chihiro Shiraki

Tadahi Hirata

Akira Horiguchi

Takashi Oshiro

Kazuyuki Iwashashi

LK6-A derivatives

Pyrrolo &lsqb;4,3,2-de&rsqb; quinoline derivatives

Process for preparing optically active 1,2-diols

Process for producing xanthine derivatives with bacteria and fungi

The invention relates to a process for producing L(-)-tetrahydrofolic acid which comprises allowing dihydrofolate reductase to act upon dihydrofolic acid in the presence of (1) NADP or NADPH, and (2) glucose and glucose dehydrogenase. L(-)-tetrahydrofolic acid is useful as the intermediate for L(-)-leucovarin.

Process for producing L(-)-tetrahydrofolic acid

Derivatives of physiologically active substance K-252

Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH.sub.2 ; n is an integer of 1 to 5; R.sub.1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R.sub.2 is a group represented by the formula: ##STR2## (where R.sub.4 is an unsubstituted or substituted phenyl or 2-aminothiazolyl) or a group represented by the formula: ##STR3## (where R.sub.5 is an unsubstituted or substituted lower alkyl); R.sub.3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R.sub.1 may be a quaternary ammonium group, where --CO.sub.2 R.sub.3 represents --CO.sub.2.sup.- ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.

3-heteroaralkylthio carbacephem compounds and antibacterial

.beta.-Lactam compounds represented by the general formula: ##STR1## (wherein X represents CH.sub.2, S or O; Y represents a hydroxyl group, a lower alkanoyloxy group or a lower alkoxycarbonyloxy group; W is a group represented by CH.sub.2, NH, ##STR2## A is a phenyl group, a naphthyl group, or a monocyclic or dicyclic heterocyclic group, respectively substituted by (Y).sub.n ; R.sub.4 and R.sub.5 each are a hydrogen atom, a lower alkyl group, or a cycloalkylidene group with a carbon atom combined therewith; l is 0 or an integer of 1, 2 or 3; m is 0 or 1; n is an integer of 1, 2, 3, 4 or 5; and R.sub.1, R.sub.2 and R.sub.3 are groups often used in the conventional .beta.-lactam compounds) have strong antimicrobial activities against a wide range of Gram positive and negative bacteria; particularly Gram negative bacteria including Pseudomonas aeruginosa, Pseudomonas sepatia and various Enterobacters.

.beta.-lactam compound and a pharmaceutical composition containing the

Carbacephem compounds represented by the formula: ##STR1## [wherein R.sub.1 is a lower alkylsulfonyloxy, unsubstituted or substituted arylsulfonyloxy, azido, cyano, carbamoyloxy, unsubstituted or substituted heterocyclic thio ('heterocyclic' means a 5- or 6-membered heterocyclic group having 1 to 4 O, S or N atoms), unsubstituted or substituted lower alkylthio, or unsubstituted or substituted arylthio group; R.sub.2 and R.sub.3 are groups frequently used in the cephalosporin chemistry] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for curing various infections.

3-substituted carbacepem compounds having antibacterial effect

Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin A.

Derivatives of fortimicin A

Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin B.

Novel derivatives of fortimicin B and process for preparing same

6'-N-methylfortimicin D and 6'-N-methylfortimicin KE are produced by chemically moidifying fortimicin KE. 6'-N-methylfortimicin D is useful as an antibacterial compound; and 6'-N-methylfortimicin KE is useful as an intermediate in the synthesis of the former compound.

Fortimicin derivatives and method for production thereof

Novel .beta.-phenoxy- or substituted phenoxy-ethanol compounds or esters thereof expressed by the formula ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group, R.sup.2 is a hydrogen atom or a substituent, Y is --OH group or group ##STR2## R.sup.3 is an alkyl group, and n is an integer of 1 to 3. These compounds have juvenile hormone activities, and are useful for hormonal pest control and increased production of silkworm cocoons.

.beta.-Phenoxy or substituted phenoxy ethanol compounds

Growing community of inventors

Hiratsuka, Japan

Kenichi Mochida