Daiichi Sankyo Company, Limited

Miura Co., Ltd.

Kenichi Kimura

Masazumi Yamashita

Junichi Nakajima

Masayuki Murakami

Yoshitaka Nakamura

Yuichi Aki

Daisuke Fukatsu

Makoto Michida

Koji Hamaoka

It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme: wherein Rrepresents a C1-C6 alkyl group, Rrepresents a C1-C6 alkyl group, and Rrepresents a C1-C6 alkyl group.

Method for producing dicarboxylic acid compound

The problem to be solved is to provide a method for producing a compound having excellent activity as an &#x3b1;&#x3b4; ligand. The solution thereto is a method for producing a compound represented by the general formula (VI) or a salt thereof via an iminium salt: [in the formula, R: a hydrogen atom or a C1-C6 alkyl group]. 

Methods for producing bicyclic compounds via iminium salt

The invention effectively prevents occurrence of corrosion in water tubes or the like of boilers. The invention provides a method for operating a boiler, including regulating a concentration of sulfate ions SO in boiler water to under 500 ppm, and a method for injecting a sulfite base oxygen scavenger, including setting a concentration of residual dissolved oxygen in boiler feed water to 2-4 ppm. The invention further provides a sulfite base oxygen scavenger composition comprising: 3-30 weight % of at least one selected from a group consisting of Na SO , K SO , NaHSO and KHSO ; 1-20 weight % of NaOH or KOH; 0.2-2 weight % of potassium sorbate; and 5-500 ppm of CoSO .

Composition for preventing corrosion using a sulfite-based oxygen scavenger

The invention effectively prevents occurrence of corrosion in water tubes or the like of boilers. The invention provides a method for operating a boiler, including regulating a concentration of sulfate ions SO.sub.4.sup.2- in boiler water to under 500 ppm, and a method for injecting a sulfite base oxygen scavenger, including setting a concentration of residual dissolved oxygen in boiler feed water to 2-4 ppm. The invention further provides a sulfite base oxygen scavenger composition comprising: 3-30 weight % of at least one selected from a group consisting of Na.sub.2 SO.sub.3, K.sub.2 SO.sub.3, NaHSO.sub.3 and KHSO.sub.3 ; 1-20 weight % of NaOH or KOH; 0.2-2 weight % of potassium sorbate; and 5-500 ppm of CoSO.sub.4.

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Matsuyama, Japan

Kenichi Kimura