Taisho Pharmaceutical Co., Ltd.

Kenichi Kawabe

Takahiro Oi

Fumiyasu Shiozawa

Tsuyoshi Shibata

Hiroyuki Kakinuma

Yohei Kobashi

Tomomichi Chonan

Yuki Iwata

Masato Takahashi

Hiroshi Ohta

Yuki Shimizu

Makoto Hamada

Tetsuo Takayama

Fumihito Ushiyama

Shoichi Kuroda

Yasunobu Ushiki

Fumito Uneuchi

Yoshihisa Shirasaki

Daisuke Matsuda

Hideaki Tabuse

Akira Hiratate

Chie Koizumi

Sota Kato

Eiji Munetomo

Sumi Chonan

The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect:A-Y&#x2003;&#x2003;[1]wherein  

Phenyl tetrahydroisoquinoline compound substituted with heteroaryl

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I&#x2032;),W, Y, R, R, R, and Yare as described hereinabove), or pharmaceutically acceptable salts thereof.

Partially saturated nitrogen-containing heterocyclic compound

A compound, which inhibits SGLT1 (sodium-dependent glucose transporter 1) activity to suppress absorption of glucose or the like, thereby suppressing abnormal glucose tolerance or postprandial hyperglycemia in diabetes, is provided. Specifically, a 4-isopropyl-6-methoxyphenyl glucitol compound represented by the following formula (I), or a pharmaceutically acceptable salt thereof, is provided: 

4-isopropyl-6-methoxyphenyl glucitol compound

The present invention provides 4-isopropylphenyl glucitol compounds which have no tendency to accumulate in the body and which inhibit SGLT1 activity to suppress postprandial hyperglycemia (or impaired glucose tolerance) through suppression of glucose absorption in the small intestine, whereby the compounds, for example, can suppress the onset of diabetes and metabolic syndrome or can treat these diseases. A 4-isopropylphenyl glucitol compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein Rrepresents a hydrogen atom, etc., Rrepresents a methyl group, etc., Rrepresents a Calkyl group substituted with an amino group(s), etc., and Rrepresents a hydrogen atom, etc.

4-isopropylphenyl glucitol compounds as SGLT1 inhibitors

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Tokyo, Japan

Kenichi Kawabe