Tokyo Tanabe Company, Ltd.

Kenichi Iizumi

Kiyokazu Murakami

Naoto Matsuishi

Akira Hisamitsu

Haruki Takeda

Imidazo[4,5-b]pyridine compounds of the general formula [I] are provided: ##STR1## where R.sup.1 is straight-chain or branched C.sub.1-8 alkoxy which may be substituted with cycloalkyl, or C.sub.2-4 fluoroalkyloxy, R.sup.2 is H, methyl or methoxy, and R.sup.3 and R.sup.4 are each H or methyl and may be the same or different. All these compounds have good activity of inhibiting potassium ion-dependent adenosine triphosphatase and excellent storage stability, so that they are usable for the treatment of gastric and/or duodenal ulcers.

Imidazo[4,5-b]pyridine compounds and pharmaceutical compositions

Benzimidazole derivatives of the general formula [I] are provided: ##STR1## wherein R.sup.1 is hydrogen, methyl or methoxy, and R.sup.2 and R.sup.3 each is hydrogen or methyl, at least one of R.sup.1, R.sup.2 and R.sup.3 being a member other than hydrogen. The benzimidazole derivatives exhibit an excellent activity of inhibiting the potassium ion-dependent adenosine triphosphatase, as well as a good stability during storage. Therefore, the benzimidazole derivatives are usable for the treatment of gastric and/or duodenal ulcers.

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Mitaka, Japan

Kenichi Iizumi