Meiji Seika Kaisha, Ltd.

Meiji Seika Kabushiki Kaisha

Meji Seika Kaisha Ltd.

Kenichi Fushihara

Yasuo Ohtsuka

Mami Kawaguchi

Takashi Shishikura

Seiji Tsutsumi

Yumiko Okada

Sohjiro Shiokawa

Toshio Nishizuka

Hideo Kitagawa

Toyoaki Ishikura

Hiromi Takata

Sachiko Miyamoto

Maki Shiobara

Takashi Tsuruoka

Tetsuya Matsushima

Hiroko Ogino

Kenichi Kanemoto

Chika Kikuchi

Takehiro Yamamoto

Shigeru Hoshiko

Koji Tsuchiya

Takako Iwasaki

Keiko Shito

Megumi Imai

Junko Tanaka

Eriko Satoh

Kokichi Suzuki

Takashi Ida

Katsuyoshi Iwamatsu

Kunio Atsumi

Toshiro Sasaki

Yuko Kano

Kazuhiro Aihara

Kazuko Kobayashi

Hiromasa Takizawa

Yumiko Toyooka

Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereon. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein Rrepresents hydrogen, OH, alkyl or phenyl alkyl, 

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents

A process for preparing a compound represented by formula (IIa')wherein Q represents group (i) as defined in the specification and Rto R, R, R, and Rare as defined in the specification, by (1) reacting a compound represented by formula (V)wherein Rto Rand Rare as defined in the specification. with a compound represented by RRC&#x2550;O wherein Rand Rare as defined in the specification; (2) reacting the compound prepared in (1) with a compound represented by R&#x2014;C(&#x2550;O)&#x2014;Rwherein Rand Reach independently represent a chlorine atom, 4-nitrophenyl, or 1-imidazolyl; and (3) reacting the compound prepared in (2) with a compound represented by ROH wherein Ris as defined in the specification.

Phosphonic acid derivative having inhibitory activity against carboxypeptidase B

Phosphonic acid derivatives having carboxypeptidase b inhibitory activity

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic

The carbapenem derivatives represented by the following formula (I) is disclosed. These compounds have strong anti-bacterial activities against bacteria including methicillin resistant,, penicillin resistant,, Enterococci, influenza, and &bgr;-lactamase producing bacteria, and have high stabilities to DHP-1

Carbapenem derivatives

Compounds of formulae (II), (III), (IV) and (V) or salts thereof are intermediates for pharmacologically active tricyclic benzazepine and benzothiazepine derivatives, ##STR1## wherein R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl, and R.sup.41 represents hydrogen, C.sub.1-6 alkyl which may be optionally substituted, or a protective group for a carboxyl group.

Triazole intermediates for tricyclic benzazepine and benzothiazepine

Tricyclic benzazepine and benzothiazepine derivatives

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Yokohama, Japan

Kenichi Fushihara