Eisai Company, Limited

Eisai Inc.

Kenichi Chiba

Hiroshi Shirota

Isao Yamatsu

Kenzo Muramoto

Takeshi Suzuki

Ryoichi Hashida

Masaki Goto

Hideki Sakurai

Shinya Abe

Toshihiko Kaneko

Jean-Christophe P Harmange

Hiroyuki Yoshimura

Shigeru Souda

Yoshimasa Machida

Shuhei Miyazawa

Mark Spyvee

Shigeki Hibi

Seiichiro Nomoto

Naoyuki Shimomura

Katsuya Tagami

Yasushi Okamoto

Richard S Clark

Tetsuya Kawahara

Koukichi Harada

Kazuo Okano

Makoto Okita

Kouichi Katayama

Satoshi Yamamoto

Tomohiro Matsushima

Naoki Yoneda

Takashi Inoue

Makoto Kotake

Yoshiyuki Kawakami

Hong Du

Hideki Ono

Fabian Gusovsky

Masayuki Tanaka

Yoshiharu Mizui

Isao Tanaka

Toru Horie

Hideto Ohhara

Takashi Mori

Yoshihito Eguchi

Yoshikazu Kuboi

John (Yuan) Wang

Masanori Fujita

Akifumi Kimura

Takatoshi Kawai

Megumi Kawada

Kenichi Kusube

Yong-Chun Shen

Roch Boivin

Yimin Jiang

Xiang-Yi Li

Jesse Chow

Charles-André Lemelin

Takashi Yamanaka

Ray Wood

Hirsohi Shirota

Akiyoshi Uchiyama

The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R-R, t, X, Y, Z, and n are as defined herein.

Macrocyclic compounds useful as pharmaceuticals

The present invention provides compositions comprising compounds having formula (I): 

The present invention provides compounds having formula (I): 

To provide a treating or ameliorating agent for joint diseases accompanied with arthritis, preferably, a rheumatoid arthritis or ameliorating agent, which exerts excellent pharmaceutical effects. The active ingredient is a quinone derivative represented by the following general formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein n is 0 or an integer of 1 to 12 and R is a methyl or methoxy group.

Therapeutic agent for treating joint diseases associated with arthritis

Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.

Naphthalene derivative

Compounds of the formula: ##STR1## where R.sup.1 is a hydrogen atom or a lower alkyl group;

Naphthalene derivatives

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

The present invention relates to a naphthalene derivative. More particularly, it relates to a naphthalene derivative exhibiting an excellent activity as a drug.

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

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Tsuchiura, Japan

Kenichi Chiba