Japan Science and Technology Agency

Kaken Pharmaceutical Company, Ltd.

Mitsui Sugar Co., Ltd.

Taito Company, Ltd.

Kengo Tabata

Seiji Shinkai

Kazuo Sakurai

Kazuya Koumoto

Taro Kimura

Toshio Yanaki

Mitsuaki Mitani

Takemasa Kojima

Oliver Gronwald

Disclosed is a gene carrier composed of a hydrogen-bonding polymer having a polymer chain with hydrogen-bonding sites formed on the polymer chain, in which the polymer chain has a conformation similar to the conformation of a nucleic acid, and particularly, the polymer chain has helix parameters similar to the helix parameters of a nucleic acid of a helix structure. In a preferred embodiment, the hydrogen-bonding polymer is composed of &#x3b2;-1,3-glucan such as schizophyllan. The carrier can be expected to be applied as a vector and a separator for nucleic acids because it is capable of interacting with a nucleic acid to form a complex with the nucleic acid and thus carrying the nucleic acid.

Gene carrier

The description describes a process for depolymerization of a polysaccharide having a rod-like helical structure, comprising a step for forcing a solution of the polysaccharide in a solvent (solvent A) through a capillary at a high shear rate, to produce a lower molecular weight degraded polysaccharide, which has the same repeating unit and the same helical structure, as those of the original polysaccharide.

Method for a specific depolymerization of a polysaccharide having a

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Kobe, Japan

Kengo Tabata