Mitsui Toatsu Chemicals, Incorporated

Mitsui Chemicals, Inc.

Kengo Otsuka

Nobuyuki Fukazawa

Tsuneji Suzuki

Takashi Tsuruo

Makoto Odate

Wakao Sato

Nobuya Kawauchi

Masahiko Maruyama

Makoto Hirayama

Tatsuo Kaiho

Hironori Komatsu

Seitaro Kajiya

Takafumi Kitano

Kunio Okumura

Hidetoshi Tsunoda

Osamu Yano

Daiji Iwata

Yuki Nakajima

Fumiaki Ikeda

Yukio Miyama

Kunio Sannohe

Tuneji Suzuki

Yukichi Kawai

Hiroki Ishibashi

Toshohiko Ito

Shimada Shizuo

A readily available and inexpensive natural &#x3b1;-amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to give an optically active 5-hydroxyoxazolidine represented by formula (3), which is then treated with an acid to provide an optically active aminoketone represented by formula (4). The product is then converted into an optically active aminoalcohol represented by formula (5) or (6) by, for example reduction.

Optically active amine derivatives and preparation process therefor

A process for producing 1-(2'-deoxy-B-D-erythropentofuranosyl)-5-trifluoromethyluracil derivatives having the formula as shown below: ##STR1## wherein X.sup.1 and X.sup.2 are independently hydrogen or halogen, comprising:

Process for producing

Process for production of glycide derivative

Compounds having an activity to stimulate the carcinostatic effect of carcinostatic agents, which can be expressed by the following general formula (1): ##STR1## in which A is ##STR2## (in which R.sub.1, R.sub.2 and R.sub.3 are each independent and represent a hydrogen atom or a phenyl group) are made into fumarates so as to improve their oral absorbability and solubility in water without interfering with their effects.

Quinoline derivative fumarates

Heterocyclic compounds useful as anticancer drug potentiaters having a potentiating effect on the incorporation of anticancer drugs into cancer cells are disclosed, the compounds each synthesized by, for example, reacting a epoxy compound obtained by reacting a heterocyclic compound with an epihalogenohydrin, with an amine derivative.

Quinoline derivatives

Catechol derivatives which produce nerve growth factor in particular tissues of the brain are disclosed. These derivatives provide preventive and therapeutic effects for regressive disorders of the central nervous system including senile dementia of the Alzheimer type.

Catechol derivatives and pharmaceutical preparations containing same

Novel heterocyclic compounds, which are represented by the following general formula, useful as anticancer drug potentiaters having a potentiating effect on the incorporation of anticancer drugs into cancer cells, the compounds each synthesized by, for example, reacting a epoxy compound obtained by reacting a heterocyclic compound with an epihalogenohydrin, with an amine derivative.

Heterocyclic compounds and anticancer-drug potentiaters conaining them

The isoquinoline derivatives represented by the following general formula (I) are useful as cardiotonics having high cardiotonic activity and low toxicity: ##STR1## where R.sub.1 represents a lower C.sub.1 -C.sub.4 alkyl group or cyclopropyl group,

Isoquinoline derivatives

Isoquinoline derivatives represented by the general formula (I): ##STR1## wherein R.sub.1 denotes a hydrogen or halogen atom, or a nitro or acetyl group, and R.sub.2 denotes a hydrogen atom, or a methyl, methoxy, phenyl, 4-pyridyl or 2-pyridyl group, and therapeutically acceptable salts thereof have high cardiotonic activity and low toxicity.

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Mobara, Japan

Kengo Otsuka