Anaeropharma Science, Inc.

Azusapharma Sciences, Inc.

Kengo Inoue

Satoshi Kobayashi

Hitomi Shimizu

Takeshi Masaki

Yuko Shimatani

Koichi Koseki

Koichiro Shioya

Tomio Matsumura

Masami Okabe

The object of the invention is to provide an anaerobic enterobacterium having a higher therapeutic effect on an anaerobic site such as a solid tumor tissue and an ischemic disease site. A bacterium of the genus, which is transformed with a plasmid co-expressing two types of heterologous polypeptides and comprising two types of secretory expression cassettes each sequentially comprising a promoter DNA functioning in the bacterium of the genus; a DNA encoding a secretory signal peptide; a DNA encoding a heterologous polypeptide; and a terminator DNA functioning in the bacterium of the genus, efficiently secretes the two types of heterologous peptides, i.e., two types of antibodies having anticancer effects, outside the bacterial cell.

Co-expression plasmid

Growing community of inventors

Tokyo, Japan

Kengo Inoue